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1、三、重要科学发现和主要技术发明、科技创新1.重要科学发现、主要技术发明、主要科技创新重要科学发现（1）房水抽吸联合激光房角光凝法建立青光眼大鼠模型，重点观察其眼压改变特征和病理改变特点,探讨其科研应用的可行性。研究结果如下表（图）：Figure1.Thephotographoftheanteriorchamberafterphotocoagulationofangleundertheslit-lampmicroscope:Theedemaofcorneaandcongestionofconjunctivaw
2、eredisplayed.Anteriorchamberformedinthefirstdayafteroperation;Corneaandlenswereclear,andvascularnetworkoniriswasvisibleon3dpostoperation.Table1IOPofrateyesafterphotocoagulation（x±s,mmHg,n=75）IOPinpost-opEyesPre-op1d3d7d14d21d28d35d42dcbcbcbcbcbcRight16.56±
3、1.8421.33±2.6425.56±2.3530.31±3.2225.67±2.3221.19±2.1817.08±1.3616.14±1.5216.28±1.58bLeft16.70±1.9317.55±1.5816.83±1.3417.45±1.3716.97±1.1517.67±0.9416.36±1.6016.23±1.5516.34±1.57Fcbgroup=122.952,P=0.000;Ftime=278.146,P=0.000；P<0.01vsrespectivelefteyes,P<0
4、.05vsrespectivepre-opvalueFig.2(A)Linegraph:RepresentativeIOPineachgroupwithineachweek.**P<0.01indicatedsignificantlydifferedfromtheIOPbaselinebyANOVA.(B)Bargraph:RepresentativeVariationinintraocularpressure(IOP)atdifferenttimepointsbeforeandaftertreatment
5、s.*P<0.05and**P<0.01indicatedsignificantlydifferencebeforeandaftertreatmentbyANOVA.ACDEBFGHFig.3H&Estainofrateyeatdifferenttime（×400）A-E:Theangleoftheanteriorchamberwasgraduallynarrow,andtrabecularmeshworkspacecompressedevendisappear.Theedemaandcurlofirisw
6、erein1,2,4,6,8weeksafteroperationintherighteyesF-H:Noobviouschangesintheanteriorchamberangle,trabecularmeshworkspaceandirisin4,6and8weeksafteroperationinthelefteye.Table2NumberofRGCsrateyeafterphotocoagulation（x±s,cells/0.024mm2,n=75）Post-opEyesPre-op7d14d
7、28d56dRight67.56±1.8560.50±1.87c58.25±1.29bc56.67±1.64bc45.56±12.33bcLeft68.50±1.6967.08±1.3868.67±3.8567.56±6.1368.33±3.25Fbcgroup=131.78,P=0.000;Ftime=20.96P=0.000;P<0.05vsrespectivelefteye,P<0.01vsrespectivepre-opvalueFig.3NisslsAtainingofratretinal（B×1
8、000）A:AloCtsofRGCswereseenDintherighteyebeEforelaserphotocoagulationB-E:ThenumbersofRGCsintherighteyeweregraduallydecreasedwithincreaseoftimeafteroperationF-J:Noobviouschangewasseeninthenumbersofretinalgangli
