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1、CorrespondenceAIDS2006,20:2399–2403Serious,multi-organhypersensitivitytolopinaviralone,involvingcutaneous-mucousrash,andmyeloid,liver,andkidneyfunctionProteaseinhibitor(PI)-relatedtoxicityappearstobe1.2mg/dl,calcium7.4mg/dl),accompaniedbyatubularmainlyrelatedtolo
2、ng-termsideeffects[13].Acasedysfunctioncharacterizedbylowurineconcentrations.reportofaserious,rapid-onsetreactiontolopinavirDuringthesubsequentweekofintensivecare,includingoccurredinanantiretroviral-experiencedpatient,under-fluid-electrolytemanagement,steroid-albu
3、minadmin-liningtheimportanceofalsoconsideringPI-associatedistration,anderythrocytetransfusion,theskinrashshort-termmulti-organtoxicity.evolvedintoadesquamativephasewithextensiveepidermaldetachment,whereasanormalizationofallA38-year-oldwomanhadbeentakingHAARTfor7y
4、earsliverkidneymyelopoieticparametersbecamealmostasaresultofasevereimmunodeficiencyatpresentationcomplete16daysafterHAARTinterruption,anddidnot(CD4cellcount102cells/ml).InadequateHAARTshowrelapsesduringthesubsequentfollow-up;afterthatadherence,limitedimmunerecover
5、y,thedevelopmentanatazanavir/ritonavir-basedHAARTregimenwasofgenotypicresistance,andsomeadverseeventshadadministered.prompted11changesinHAARTuptothesummerof2006.WhenconsideringpreviousPI,non-boostedInourcasereport,theclinicalhistoryallowspreviousindinavirwasinter
6、ruptedbecauseofkidneycolic,full-hypersensitivitytoco-administeredfluconazoleatova-doseritonavirwassuspendedbecauseofpoorcompliance,quonetobeexcluded,whereaslamivudineandstavudinecombinedindinavirritonavirwerewithdrawnasaresulthadbeenpreviouslyadministeredforaveryl
7、ongtimeofgenotypicresistance,aswellasasubsequentcourseof(4836months).There-introductionofHAARTwasnelfinavir.Tenweeksagoourpatientdevelopedoeso-alsodelayedfor3weeksafterfluconazoletherapybecausephagealcandidiasis.HAARTwasspontaneouslyinter-ofoesophagealcandidiasis,i
8、nordertoavoidanruptedbeforehospitalization,whenherCD4cellcountimmunoreconstitutionsyndrome.Thelopinavir/ritona-was58cells/ml.Threeweeksaftercuringthecandidiasi
