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1、.AGoodPracticeGuidetotheAdministrationofSubstancesandRemovalofBlood,IncludingRoutesandVolumes良好的实验动物给药和采血(包括途径和体积)规范指南Karl-HeinzDiehl1,RobinHull2,DavidMorton3,RudolfPfister4,YvonRabemampianina5,DavidSmith6,*,Jean-MarcVidal7andCorvandeVorstenbosch81Aventis,POBox1140,D35001Marburg,Germany德国马尔堡市350
2、01区1140信箱安万特公司2NIBSC,BlanchLane,SouthMiimms,PottersBar,HertfordshireEN63QG英国赫特福德郡EN63QG波特斯巴镇SouthMiimms布兰奇道英国国家生物制品检定所3TheUniversityofBirmingham,MedicalSchool,Edgbaston,BirminghamB152TT英国伯明翰市B152TT艾吉马斯顿伯明翰大学医学院4NovartisPharmaAG,CH-4002Basel,Switzerland瑞士巴塞尔CH-4002诺华制药公司5CentredeRecherchePfizer,E
3、tablissementd’Amboise,Z1Poce´-sur-Cisse-BP15937401AmboiseCedex,France法国AmboiseCedexZ1Poce´-sur-Cisse-BP15937401Etablissementd’Amboise辉瑞研究中心6AstraZenecaR&DCharnwood,BakewellRoad,Loughborough,LeicsLE115RH英国莱斯特郡LE115RH拉夫堡市贝克韦尔路Charnwood阿斯利康研究中心7Aventis,102RoutedeNoisy,95235RomainvilleCe´dex,France法
4、国RomainvilleCe´dex95235Noisy路102号安万特公司8NVOrganon,POBox20,5340BHOss,Netherlands荷兰BHOss534020号信箱欧加农公司Keywords:bloodvolumes;bloodremoval;administrationsubstances;laboratoryanimals;refinement.关键词:血容量;采血;给药;实验动物;简化ThisarticleistheresultofaninitiativebetweentheEuropeanFederationofPharmaceuticalIndustr
5、iesAssociations(EFPIA)andtheEuropeanCentrefortheValidationofAlternativeMethods(ECVAM).Itsobjectivesaretoprovidetheresearcherinthesafetyevaluationlaboratorywithanup-to-date,easyto-usesetofdatasheetstoaidinthestudydesignprocesswhilstatthesametimeaffordingmaximumwelfareconsiderationstotheexperiment
6、alanimals.该文章为欧盟制药工业协会(EFPIA)和欧洲替代动物实验方法验证中心(ECVAM)Word资料.之间的初步结果。其目的在于为安全性评价实验室的研究者提供最新的易于使用的数据库以帮助研究设计过程,同时最大可能地考虑到实验动物的福利。AlthoughthisarticleistargetedatresearchersintheEuropeanPharmaceuticalIndustry,itisconsideredthattheprinciplesunderpinningthedatasetsandrefinementproposalsareequallyapplica
7、bletoallthosewhousethesetechniquesonanimalsintheirresearch,whetherinresearchinstitutes,universitiesorothersectorsofindustry.Theimplicationsofthisarticlemayleadtodiscussionwithregulators,suchasthoseresponsibleforpharmacopoeia