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1、Abstractsofthe4thBiennialSchizophreniaInternationalResearchConference/SchizophreniaResearch153,Supplement1(2014)S1–S384S81Results:Intwoseparatecohorts,cognitivefunctionshowednoevidenceCOGNITIVETRAJECTORYBETWEENAGES10,13AND18ANDRISKFORofdeteriorationfollowingpsychosisonset.This
2、wastrueforIQandspe-PSYCHOSISINADULTHOOD:ASWEDISHLONGITUDINALCOHORTSTUDYcificcognitivedomains.Therewasimprovementinseveraldomainsbut,whencomparedtochangesinthecontrolgroupovertime,thesewereJamesH.MacCabe1,MizanurKhondoker2,SusanneWicks3,SofiaLöfving3,attributabletopracticeeffects
3、.AsubstantialsubgroupshowedevidenceofAnthonySionDavid2,ÅsaBerndtsson4,Jan-EricGustafsson4,cognitivedeclinealreadypresentatthetimeofpsychosisonset.ForbothPeterAllebeck3,ChristinaDalman3cohorts,cognitionatonsetpredictedfunctionaloutcome3-4yearslater.1DepartmentofPsychosisStudies
4、,InstituteofPsychiatry,King’sCollegeInasubgroupofpatients,MRImeasuresofcorticalthicknessandareaatLondon,UK;2InstituteofPsychiatry,King’sCollegeLondon,UK;3Departmentpsychosisonsetshowedreducedfronto-temporalcorticalareacomparedofPublicHealthSciences,KarolinskaInstitutet,Stockho
5、lm,Sweden;tocontrolsandthedegreeofareareductionwasrelatedtocurrentand4DepartmentforEducationandSpecialTraining,UniversityofGothenberg,premorbidIQ.Whenpatientsandcontrolswereexaminedameanof2Swedenyearslatertherewasareductioninthethicknessofthefrontalcortexand,Background:Thereis
6、nowclearevidencethatpatientswithschizophreniatoalesserextent,theparietalcortex,butnochangeinarea.Althoughtheresufferfromavarietyofcognitivedeficitsduringchildhoodandadolescence.wasnoconcomitantdeteriorationincognitivefunctionoverthisperiod,IQHowever,verylittleisknownaboutthecou
7、rseofpremorbidcognitionoverandworkingmemoryatpsychosisonsetpredictedthedegreeofthinningthepremorbidperiod.AIMS:Toassesstheimpactofcognitivedevelop-offrontalandparietalcortexinpatientstwoyearslater.MEGanalysismentaltrajectoryinadolescenceonriskforschizophreniainadulthood.wascon
8、sistentwiththehypothesisthatfunctionaldisconnectionintheMetho
