第五六章多组分反应和串联反应.ppt

《第五六章多组分反应和串联反应.ppt》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、第五章Multi-ComponentReactionsMulticomponentsreactions(MCRs)arethosereactionsinwhichthreeormorereactantscometogetherinasinglereactionvesseltoformanewproductwhichcontainsportionsofallthecomponentsMCRA+B+C….PConvergencyComplexityProductivitySelectivityAtomeconomyDiversity一、多组分反应的历史IvarKar

2、lUgi(1930-2005),theinventorofthemostsignificantisocyanidebasedMCRs.二、多组分反应涉及的反应机理1.离子机理异腈参与的多组分反应大多为离子机理。Angew.Chem.Int.Ed.1998,37,22342.自由基机理Angew.Chem.Int.Ed.2003,42,34903.周环反应机理TetrahedronLett.1998,29,58554.混合机理自由基和负离子组合Angew.Chem.Int.Ed.1998,37,152三、金属催化的多组分反应四、多组分反应展望Hardlyafiel

3、dinorganicchemistryhasevolvedfasteroveronlyacoupleofyearsthanMCRs.However,theverylargeMCRspaceof>1020isonlyexploredmarginally.FutureresearchintheareaofMCRswillincludethediscoveryanddesignofnovelMCRs,combinationsofMCRsandtraditionalreactions,experimentalimprovementsinsolid-andliquid-p

4、hase,enantio-anddiastereo-selectivevariations,andmoreandmoreapplicationsindrugdiscovery,materialscience,bioconjugates,andagrochemicalcompounds.第六章串联反应新进展串联反应（Tandemreaction）串级反应(Cascadereaction)多米诺反应(Dominoreaction)连续反应(Sequentialreaction)Tandemreactions,inwhichmultiplereactionsareco

5、mbinedintoonesyntheticoperation,havebeenreportedextensivelyinthesyntheticchemistryliterature....Angew.Chem.Int.Ed.2009,48,7064–7068重排反应自由基反应Michael加成反应过渡金属催化的反应Fischer卡宾配合物的反应周环反应其他反应