最新流行病学文献评价报告.doc

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1、幻灯片1 临床流行病学幻灯片2l学生姓名：l班级:l学号：l本（专）科专业：临床医学l现攻读专业：老年医学l导师：幻灯片3幻灯片4l评价论文题目：Associationbetweenlow-dosefolicacidsupplementationandbloodlipidsconcentrationsinmaleandfemalesubjectswithatherosclerosisriskfactors.l出处：MedSciMonit.2013;19:733–739.l设计类型:DRUGCONTROLLEDSTUDIESl药物对照研究论文性质：预防幻灯片5幻灯片6lThea

2、imofthisstudywastoanalyzetheassociationoflow-dosefolicacidsupplementationwithbloodlipidsconcentrationsinsubjectswithatherosclerosisriskfactors.lMaterial/MethodslThestudyenrolled124Caucasianindividuals(60M,ages20–39;and64F,ages19–39)withatherosclerosisriskfactors(familyhistoryofprematureisch

3、emicstroke,arterialhypertension,dyslipidemia,overweightandobesity,cigarettesmoking,andlowlevelofphysicalactivity).TheparticipantswereaskedtotakeFAatalowdoseof0.4mg/24hfor12weeks.lResultslFAlevelsincreasedinfemales(6.3vs.12.5ng/dL;p=0.001)andmales(6.4vs.11.4ng/dL;p=0.001)andHcylevelsdecrease

4、d(10.6vs.8.3μmol/L;p=0.001and11.5vs.9.3;p=0.001,respectively).Asignificantreductioninmeanconcentrationoftotalcholesterolinfemales(203.4vs.193.1mg/dL;p=0.001)andinmales(209.5vs.201.9;p=0.002)wasobserved.Thelow-densitylipoproteincholesterol(LDL-C)levelsdecreasedinfemalesandinmales(107.4vs.99.

5、9mg/dL;p=0.001and121.5vs.115.1;p=0.002,respectively).TheapoAIconcentrationsincreasedinsmokingwomenandinmenwithBMI≥25kg/m2(p=0.032andp=0.024,respectively).lConclusionslLow-doseFAsupplementationhasabeneficialeffectonbloodlipidsthroughdecreasingconcentrationsoftotalcholesterolandLDL-Candincrea

6、singconcentrationsofapoAI.幻灯片7幻灯片8lHowever,thepreventiveeffectofFAoncardiovasculardiseaseremainsunclear.Large-scaleclinicaltrialsfailedtoshowabenefitfromHcy-loweringtreatmentinindividualswithestablishedcardiovasculardiseaseorwithhistoryofmyocardialinfarction.However,thosestudiesevaluatedhig

7、h-doseFAsupplementationassecondarypreventionandwerenotinvestigatinglow-doseFAsupplementationasprimarypreventionofcardiovasculardisease.文章的提出有科学性，有创新性，可行性，与临床密切相关幻灯片9l类型：药物对照（自身前后对照），临床试验性研究l样本选择：Initially,FAsupplementationwasofferedto147subjects,23ofwhom