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1、ABSTRACTObjectiveTostudytheclinicalcharacteristicsofhepatocellularcarcinoma(HCC)withthenegativealpha-fetoprotein(AFP),andevaluateitsprognosticfactors・Methods30patientswithAFP-negativeHCCand101caseswithAFP-positiveHCCtreatedbyhepatectomyinourhospitalfromJanua
2、ry2005toJanuary2007werecomparedingeneraldatas(sex,age,alcoholabuse、clinicalmanifestations),basicdiseases(HBsAg,anti-HCV,hapaticcirrhosis,Child-Pughgrading),intraoperativesituation(tumorsize,envelope,satellitelesions,tumorembolus,operativetechnique)andhistopa
3、thologicalgrading・Follow-upswereachievedon26patientswithAFP-negativeHCCand93caseswithAFP-positiveHCCrespectively,theircumulativesurvivalrateof1,3,5-yearweredescribedandcompared,andanalysisontheriskfactorsforpostoperativesurvivalofAFP-negativeHCCwasdone・Resul
4、tsThepresencesofemaciation/weakness,abdominalpainandabdominalmassinAFP・negativeHCCpatientswerelessthanthoseinAFP-positiveHCC(53.3%vs81.2%,56.7%vs76.2%,133%vs44.6%,PV0.05,0.05and0.05,respectively)・AFP-negativeHCCpatientswerelessco-infectedwithhepatitisBvirust
5、hanAFP-positiveHCC(66.6%vs90.1%,P<0.05)・Child-PughAinAFP-negativeHCCinpatientswasmorethanthatinAFP-positiveHCC(96.7%vs82.2%,PV0.05)・Furthermore,AFP-negativeHCCpatientshavemoresmallsizetumors(56.7%vs31.7%,P<0.05),whilelesssatellitelesionsandtumorembolus(10.0%
6、vs28.7%,3.3%vs18.8%,P<0.05and0.05respectively)・PatientswithcurativeresectioninAFP-negativeHCCweremorethaninAFP-positiveHCC(86.7%vs68.3%,P<0.05)・Therewerenosignificantdifferencebetweenthetwogroupsinsex,age,alcoholdependence,jaundice,ascites,anti-HCV,hapaticci
7、rrhosis,tumorenvelopeandhistopathologicalcumulativesurvivalrateof1,3,5-yearinAFP-negativeHCCpatientswerehigherthanthatinAFP-positiveHCC(89.8%vs71.6%,64.7%vs41.8%,56.6%vs29.7%,PV0.05,0.05and0.05,respectively).Univariateanalysisindicatedthathapaticcirrhosis,tu
8、morembolus,operativetechnique,andhistopathologicalgradingwererelatedtopostoperativesurvivalofAFP-negativeHCC(P<0.05,0.05,0.05,and0.05,respectively)・Multivariableanalysisshowedhapaticcirrhosis,op
