临床八年制生物化学(二)双语课程教案

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1、TheEnglish-ChineseBilingualTeachingandLearningOutlineofBiochemistryII(EnglishVersion)ChapteroneNucleotideandNucleicacidsPropose:1.Graspofthenucleotidestructure,includingthecomponentofthenucleotideandthechemicalbondslinkingthecomponents,andthenamesandabb

2、reviationsofbases,nucleosidesandnucleotides・2.ProfoundgraspofthekeyknowledgeofthestructureandfunctionofDNAandRNA.3.Familiaritywiththephysio-chcmicalpropertiesofDNAandtherelationbetweenthesepropertiesandtheDNAstructure.4.Toknowthetechniqueofisolationandp

3、urificationofnucleicacidsandDNAsequencing.Contents:1・Generalconceptsofnucleicacids・(1)Nucleotidesarcthebuildingblocksofnucleicacids.(2)Nucleotideiscomposedofbase,pentose,andphosphate・(3)The35phosphodiesterbondlinksnucleotides,manynucleotidesarelinkedby

4、the359phosphodiesterbondtoformnucleicacids.(4)NucleicacidsaredividedintoDNAandRNA.(5)Otherfunctionsofthenucleotides.2.thethreedimensionedstructureofDNA(1)DoublehelixstructureisthesecondarystructureofDNA.①ThedoublehelixDNAmodelputforthbyWastonandCrick.②

5、ThefeaturesofdoublehelixDNA.③A-DNAandZ-DNA.④TriplestrandDNA.(2)SupercoilsofDNA①ProkaryoticcircularsupercoiledDNA・②EukaryoticmtDNAandctDNA.(3)Topoisomerases.(3)Eukaryoticchromosome①Nucleosome.②Fromchromosometochromatinandchromosome・(4)DNAisthegeneticmate

6、rial①Avery'sexperiment・②Thegenome.③Euchromatinandheterochromatin・3.StructureandfunctionsofRNA(1)FourmainkindsofRNA(2)mRNA:structureandfunction.(1)tRNA:structureandfunction・(2)rRNA:structureandfunction.(3)OthersmallRNAs.2.Physico-chemicalpropertiesofnucl

7、eicacids(1)Hydrolysis.(2)UVabsorbance・(3)Denaturation,renaturation,andhybridization.3.Nuclease(1)Ribonuclease・(2)Dexoyribonuclease.4.TechniquesofisolationandpurificationofnucleicacidsandDNAsequencing・(1)Methodsofisolationandpurificationofnuceicacids.(2)

8、DNAsequencing.ChaptertwoNucleotidemetabolismPurpose1.Toknowdigestionandabsorptionofnucleicacidsandanabolismpathwayofnucleicacidsinthehumanbody.2.Profoundgraspoftherawmaterialofpurincandpyrimidinesynthesis,theendproductsofpurinean