2、大鼠空间探索实验中穿越原目标的次数。NS组海马细胞体积变大、核变小、有核仁消失和核固缩；除假手术组正常外，其余各组海马细胞层次有减少，但细胞排列比较密集、细胞形态尚可。结论和血益智方可改善VD大鼠的学习记忆能力。【关键词】 血管性痴呆；MORRIS水迷宫；学习记忆；海马 〔Abstract〕Objective To study the effects of Hexue Yizhi Formula on learning and memory and the morphology of the hippocam
3、pal neurons of the rats with Vascular Dementia (VD). Methods The rats were subjectedfor ischemia-reperfusion repeatedly by blocking the bilateral common carotid arteries to establish VD models. Theywere divided into four groups randomly after the establishm
4、ent of VD model. The treating groups were administratedwith Hexue Yizhi Formula (1 mL/100 g)、Hexue Yizhi Formula (2 mL/100 g)、Sermion、Natural Salt Solution (NS) respectively. Animals with the shamed-operation were taken as control. The behavior changes were obse
5、rvedthrough the Shuttle box test and water maze test at the end of treatment. Results In shuttle box test Stimulus Frequency (SC)、Stimulated Time (ST) and Active avoidance Response Time (ART) of the rats were reduced respectively in Sermion、Hexue Yizhi Form
6、ula (1 mL/100 g)、Hexue Yizhi Formula (2 mL/100 g) groups than thosein NS group. In the Morris water maze test, Stage of Latency and Pathway were declined and the times were increased markedly acrossing the target. The structure levels of hippocampal neurons re
7、duced, but cells were more normal andintensive in treated groups except NS group. Conclusion Our study suggest that Hexue Yizhi Formula can improve the ability of the leaning and memory of the rats with vacular dementia and improve the clinical symptoms of
