欧哈勒OHara连续式包衣机性能及优势

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1、1April2011Tablets&CapsulestabletcoatingAdvantagesofcontinuousJamesMarjerampharmaceuticaltabletcoatingO’HaraTechnologiesManytabletmanufacturershavebecomeinterestedincontinuous•Faster,easier,andlessexpensivescale-upfromR&Dtabletcoatingtoreplaceorsupplementtraditionalbatc

2、h-styletopilot-scaleoperationandfrompilot-scaleopera-tabletcoating.Thisarticlediscussesthereasonsfortheirinteresttiontoproduction.Allscale-upcanbedoneinsimi-larmachinesordrumsizes;andweighstheadvantagesanddisadvantages.Italsodiscusses•Abilitytovarybatchsizesaccordingto

3、producttheimportanceoftabletmovementthroughcontinuouscoaters.requirementsanddemand.It’spossibletocoat150-to30,000-kilogrambatchesinasinglemachine;ormanydecades,pharmaceuticalmanufacturershave•Increasedequipmentutilizationandthuslessdown-reliedonbatchoperations,sowhywou

4、ldtheynowcon-timebecausetheequipmentspendsmoretimecoat-sidFercontinuoustabletcoatingorothercontinuousoper-ingandlesstimeinunproductiveprocesssteps;andations?Thereareseveralreasons:•Containedprocesses—fromstarttofinish—arebenefi-•Potentialtoemployon-lineorat-lineprocess

5、analyt-cialforpotentproducts.Theyreduceoperatorexpo-icaltechnologytoreducetheneedforlaboratory-suretotheAPIandotherdustsandminimizecleaning.basedqualitycontrolandtheassociatedholdpointsCreationofafullycontinuous,fullyautomatedsolidlab-basedtestingrequires;dosagetabletm

6、anufacturinglineis,somepeoplesay,theTablets&CapsulesApril20112HolyGrailofthepharmaceuticalindustry.UnlikethatEvolutionofcontinuouscoatinglegendarychalice,however,continuouscoatingappearsContinuousfilmcoatingisnotanewtechnology.Ittobewithinourgrasp,andpartofitmightlooks

7、ome-hasbeenusedintheagriculturalseedindustryformanythinglikethediagraminFigure1.Listedbelowareyetyears.Infact,thepolymersusedtocoatseedsaresimilarmoreadvantagesofcontinuouscoatingandsomeofthetothepolymersusedtocoattablets;botharebasedoneconomicbenefitstheyentail:hydrox

8、ypropylmethylcellulose.Thusitisnosurprise•Lessproductloss,lessproductdamage,andhigherthatseed-coatingtechnologyevolve