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1、疏风止嗽方治疗咳嗽变异性哮喘临床研究摘要：目的评价疏风止嗽方治疗咳嗽变异性哮喘(CVA)的临床疗效。方法将120例CVA患者随机分为中药组、西药组、中西组各40例。中药组口服疏风止嗽方，西药组吸入沙美特罗替卡松粉吸入剂(舒利迭)，中西组予疏风止嗽方+舒利迭，疗程均为28do观察3组治疗前后中医证候积分、咳嗽自测量表评分、嗜酸性粒细胞(EOS)计数、IgE计数、肺功能指标。结果中药组、西药组、中西组愈显率分别为45.00%、20.00%、85.00%,总有效率分另U为97.50%、77.50%、95.00%,组间比较差异有统计
2、学意义(P0.05)。3组治疗后比较肺功能指标均明显改善(P0.05)。3组支气管激发试验转阴率比较差异无统计学意义(P>0.05)o结论疏风止嗽方治疗CVA具有良好的临床疗效，其作用机制可能是抗变态反应炎症、降低气道反应性。关键词：疏风止嗽方；咳嗽变异性哮喘；临床研究DOI：10.3969/j.issn.1005-5304.2016.12.008中图分类号：R259.622.5文献标识码：A文章编号：1005-5304(2016)12-0030-04ClinicalStudyonCoughVariantAsthmaTrea
3、tedwithShufengZhisouFormulaLUShi-xiul,LIBu-manl，YINLi-hul,XIANGPing-chaol,ZHANGEr-mingl,WANGXue-jing2,QUYu-min3,ZHENGYu-qin4,LIUPei-hongl,PANGLeil(1.PekingUniversityShougangHospital,Beijing100144,China；2.China-JapanFriendshipHospital,Beijing100029,China；3.XuanwuTCM
4、Hospital,Beijing100050,China；4.ShijingshanHospital,Beijing100043,China)Abstract：ObjectiveToevaluatetheclinicalefficacyofShufengZhisouFormulaintreatingcoughvariantasthma(CVA)・MethodsTotally120CVApatientswererandomlydividedintoTCMgroup,WMgroupandintegratedTCMandWMgro
5、up,with40casesineachgroup・TCMgroupwastreatedwithShufengZhisouFormula；WMgroupwastreatedwithSeretide；integratedTCMandWMgroupwastreatedwithShufengZhisouFormulaandSeretide・Onecourseoftreatmentwastwenty・eightdaysforeachguoup・TCMsyndromescores,selftestingcoughscores,EOSn
6、umbers,IgEconcentrationandlungfunctionbeforeandaftertreatmentinthethreegroupswerecompared・ResultsThemarkedlyeffectiveratewas45.00%intheTCMgroup,20.00%intheWMgroupand85.00%intheintegratedTCMandWMgroup・ThetotaleffectiverateofTCMgroupwas97.50%intheTCMgroup,77.50%inthe
7、WMgroupand95.00%intheintegratedTCMandWMgroup,withstatisticalsigrdficance(P0.05)・Thelungfunctionofthethreegroupssignificantlyimproved(P0.05).Thediffereneeonbronchialprovocat:iontestnegativerateamongthethreegroupswaswithnostatisticalsignificanee(P>0.05)・ConclusionShu
8、fengZhisouFormulahasgoodclinicalefficacyintreatingCVA・Theactionmechanismmayberelatedtoanti-allergicinflammationandreducingairwayresponsiveness・Ke
