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1、2006年5月中国比较医学杂志May,2006第16卷第5期CHINESEJOURNALOFCOMPARATIVEMEDICINEVol.16No.5研究报告BALBc系裸小鼠脏器重量、脏器系数的测定112111练有文,王晖,倪少凯,张志,陈荣花,钟秀霞,黎石富(1.广东医学院实验动物中心,湛江524023;2.广东医学院预防医学教研室,湛江524023)【摘要】目的测定SPF级BALBc裸小鼠脏器重量、脏器系数的生物学特性指标。方法选用成年SPF级BALBc裸小鼠38只,雌雄各半,分别测定体重和12个
2、脏器重量,计算脏器系数。结果雌雄裸小鼠肾、脑重量差异有显著性(P<0.01),体重、心、肝、肾上腺重量差异有显著性(P<0.05),脑系数、肾上腺系数差异有显著性(P<0.01)。肾系数差异显著(P<0.05)。雄性裸小鼠体重与心、肝、肾、脑、肾上腺、睾丸有线性关系。雌性裸小鼠体重与肝、肾、胃有线性关系。结论BALBc雌雄裸小鼠的体重、心重量、肝重量、肾重量、脑重量、肾上腺重量、肾系数、脑系数、肾上腺系数具有差异,其体重与某些脏器存在一定的线性关系。【关键词】无特定病原体;小鼠,近交BALBc;脏器重量
3、;脏器系数【中图分类号】Q95_331【文献标识码】A【文章编号】1671-7856(2006)05-0285-03MeasurementofOrganWeightandOrganCoefficientinBALBcNudeMice1121111LIANYou_wen,WANGHui,NIShao_kai,ZHANGZhi,CHENRong_hua,ZHONGXiu_xia,LIShi_fu(1.LaboratoryAnimalCenter,GuangdongMedicalCollege,Zhanjia
4、ng524023,China;2.DepartmentofPreventiveMedicine,GuangdongMedicalCollege)【Abstract】ObjectiveTomeasuretheindexesofbiologicalcharacteristicsoforganweightandorgancoefficientofSPFBALBcnudemice.Methods38SPFBALBcnudemice(19malesand19females)werechosen,andthebod
5、yweightand12organs'weightweredetermined,thentheorgancoefficientswerecounted.ResultsBetweenfemaleandmalenudemice,thekidneyweightandbrainweightshowedsignificantdifference(P<0.01)andthedifferenceofweight,heart,liver,adrenalglandweightwasobvious(P<0.05),thec
6、oefficientofbrain,adrenalglandhadremarkablysignificantdifference(P<0.01)andthecoefficientofkidneywasobvious(P<0.05).Linearanalysisshowedthattherewereobviouslinearrelationsbetweenbodymasswithheart,liver,kidney,brain,adrenalglandandtesticleinmalemice;there
7、werelinearrelationsbetweenbodyweightandliver,kidney,andstomachinfemalemice.ConclusionDifferencesexistedinweight,heartweight,liverweight,kidneyweight,brainweight,adrenalglandweight,coefficientsofkidney,brain,andadrenalglandbetweenfemaleandmalenudemice,and
8、therehadlinearrelationshipsbetweenbodyweightandorgans.【Keywords】Specificpathogenfree(SPF);Mice,InbredBALBc;Organweight;Organcoefficient无胸腺裸鼠(nudemice)目前已成为医学生物学器重量、脏器系数和体重等指标的测定结果,并对雌领域中不可缺少的实验动物,尤其是在肿瘤学、免疫雄裸小鼠脏器重量、脏器系数进行比
