文献抄读精美PPT模板

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1、H-FABPIsMoreSensitiveThancTnIandCKMBatEarlyStageinDeterminingMyocardialInjuryCausedbyPCIFrom:IntHeartJLeventOzdemirMD2011SUMMARYMETHODSRESULTSDISCUSSIONSUMMARYMeasurementofcirculatingcardiacbiomarkershasenabledearlydiagnosisandriskassessmentofacutecoronarysyndrome.Hea

2、rttypefattyacidbindingprotein(H-FABP)isarelativelynovelmarkerforthediagnosisofmyocardialinjury.ThepurposeofthepresentstudywastocompareH-FABPwithearlystageofpercutaneouscornaryintervention(PCI).H-FABPcanbeusedinearlystagestodetectmyocardialinjurycausedbyPCI.H-FABPismor

3、esensitivethancTnIandCKMBindeterminingmyocardialinjuryduetoPCIwithin3hours.Coronaryarterydiseaseistheleadingcauseofmortalityinthedevelpedcountries.Advancesintechniquesforthemeasurementofcirculatingtroponinandcreatinekinasemyocardialbandlevelshaveenabledearlydiagnosisa

4、ndriskassessmentofmyocardialinjuryinpatientspresentingwithacutechestpain.Inaddition,H-FABPhasrecentlyemergedasanewcirculatingcardiacbiomarker.ThisstudywasdesignedtoclarifywhetherH-FABPisassensitiveascTnIandCKMBatdetectingmyocardialinjuryduetoPCIinearlystage.Weenrolled

5、40consecutivepatientswithelectivePCIwhowereadmittedtotheoutpatientclinicofaresearchhospitalinAnkara.METHODSAge59.8Male26Hyperlipidemia11Diabetesmellitus7Smoking12Hypertension13Bloodwaswithdrawnonehourbeforeand3hoursafterPCIfromthepatientstomeasurecTnI,CKMBandH-FABP.CK

6、MBandcTnIweremeasuredbyasandwichenzyme-linkedimmunosurbentassay.H-FABPwasmeasuredqualitatively.METHODSNoneofthepatientshadelevationincTnIandCKMBorpositiveH-FABPbeforethePCI.While3hoursafterPCI,therewere15patientswithH-FABPelevation,11withcTnIelevationand8withCKMBeleva

7、tion.RESULTSDISCUSSIONItisimportanttodetectmyocardialinjurycausedbyPCIsinceitmayhelpustoidentifypatientsathighriskforfuturemajorcardiacevents.TroponinsandCKMBlevelshaveenabledthediagnosisandriskassessmentofacutemyocardialinjury.Thus,abiomarkerwhichcanbedetectedintheea

8、rlyphaseofmyocardialinjuryisneeded.ItmaybeH-FABP.H-FABPcaneasilybemeasuredqualitativelywithin15minutes.Theresultsofthepresen