20种中药及其复方抗真菌实验与临床分析

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1、:大风子、皂角、川椒、明矶、董香、地骨丿目的：测定单味中药及不同复方抑真菌MIC,筛选抗真菌药纱选择合适的抗;冑中药复方治疗手足癣。方法：实验采用试管内药基法，通过单味中药实验研究’（先出有效抗真菌药物，结合中医理论，组成不同复方，进行实验研究。然后，将复:龙用于临床，进行临床疗效评价。卬菌作用最强，对皮肤癣菌MIC在1.25%~2・5%之间。只有大风子、川椒、苦参在丿■西浓度内对白色念珠菌达到抑菌效果。通过不同治则组成的复方抑皮肤癣菌MIC彳_--一一…■_•播订头风子、L625%〜1.25%之间。对白色念珠菌也有一定的抑制作用，MIC在10%〜20%之间。；正治疗手足癣疗效好于单独应

2、用杀虫药，疗效与1%特比蔡芬相当笆角、川椒、明矶、霍香、地骨皮抑菌作用最强。通过不同治则组成的复方抑菌强丿匀明显提髙。通过实验室筛选，结合辨证用药组成复方治疗手足癣疗效最好。关键词真断）中药；侯验研弦）临床研究）、ClinicalandExperimentalStudyonantifungalEffectsofTwentyChineseHerbsandCompoundsSpeciality:dermatolotysurgeryofTCMAuthor:YuTenglktor:DuXixianAbstractObjective:ToexamineMICofthesingleChinesehe

3、rbandthecompoundsaselectappropriateanti-fiingaldrugsandselectappropriateanti-fungalcompoundtotreattiimanuumandtineapedis.Method:Withadoptingthetubediskapproach,theeffectanti-fungalherbsareselectedbyexperimentalstudyofasingleChineseherb.WcombiningthetheoryofTCM,differentcompoundsareformedandstudie

4、d.Thendifferentcompoundsareusedintheclinicalcases.Andtheclinicalcurativeeffectevaluated.Results:ManyherbsincludingHydnocarpusanthelminticaPierre>GleditsinensisLam、ZanthoxylumbungeanumMaxim、Alunite、Pogostemoncablin(Blan

5、astronglyinhibitoryeffectondermatophyte(MIC:1.25%〜2.5%).TherenothingbutthreeherbsincludingHydnocarpusanthelminticaPierre.ZanthoxylibungeanumMaximandSophoraflavescensAit,thatinhibitthegrowthofCandalbicans.Chineseherbalcompoundsbasedonthedifferenttreatmentprincipalcaninhi■thegrowthofdermatophytetoa

6、certainextent(MIC:0.625%~1.25%),andatthesatimecaninhibitthegrowthofCandidaalbicans(MIC:10%~20%).Thereisasignificdifferencebetweenthetreatmentgrouponeandthetreatmentgrouptwo(P<0.05).Athereisnodifferencebetweenthetreatmentgrouponeandcontrolgroup(P>0.CConclusion:HydnocarpusanthelminticaPierre、Gledit

7、siasinensisLam%ZanthoxylibungeanumMaximaAlunite、Pogostemoncablin(Blanco)Bentli,andtherootofLyciichinenseMillxanstronglyinhibitthegrowthoffungus.Thecompoundsbasedondiffer浅部真菌病为一慢性传染病，近年来，浅部真菌病发病率有增髙趋势。手足癣:IIIIII良常见的浅部真菌