郭明美药剂学专业实验

《郭明美药剂学专业实验》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、药剂学专业实验论文学校：青岛科技大学学院：化工学院专业班级：药物制剂09级1班指导老师：公衍玲姓名：郭明美学号：0901011628复方双黄连胶囊的研制郭明美，刘旗，陈艳青岛科技大学化工学院，山东青岛266042摘要：目的通过对复方双黄连胶囊制备的整个过程，掌握常用的中约提取方法及原理，旋转蒸发仪、真空干燥器的使用；熟悉湿法制粒过程；根据《屮国药典》规定掌握胶囊剂项下的质量检查项目和检查方法;掌握薄层色谱的操作技术、崩解仪、及紫外分光光度计的使用；利用统计法观察双黃连对二甲苯所致小鼠耳肿胀的作用。方法水煎黒法提取金银花、连翘和黄苓，湿法制粒制备胶囊，薄层鉴别法进行胶囊剂鉴别，使用崩

2、解仪测定胶囊的崩解时限，双波长分光光度法测定双黄连胶囊屮黄苓首含量，用小鼠耳肿胀模型进行双黄连胶囊的药效学研究。结果四个组合作用水煎法提取中约共制得到复方双黄连胶囊40粒，胶囊质量符合要求，制备的胶囊具有抗炎作用。结论用水煎煮法提取屮药成分，制备出的复方双黄连胶囊对小鼠具抗炎作用，且药量越大，抗炎效果越好。关键词：复方双黄连，胶囊，湿法制粒，鉴别，检查，含量测定，药效学PreparationofcompoundShuanghuangliancapsulesGuoMingmci,LiuQi,ChcnYemCollegeofChemicalEngineering,QingdaoUniv

3、ersityofScienceandTechnology,Qingdao266042,ChinaAbstfact:objectiveFromthewholepreparationprocessofcompoundShuanghuangliancapsules,tomastertheusuallyextractionmethodsandprinciplesoftraditionalChinesemedicine,theuseofRotatingevaporationinstrumentandvacuumdryer;Toknowtheprocessofmakingwetgranulat

4、ion;accordingtoChinesePharmacopoeia,tomasterthemethodsfortheexaminationofthequalityofthecapsulesandpharmacodynamicresearchmethods;tomasterThinlayerchromatographytechniqueandtheuseofDisintegrationapparatusandUvspectrophotometry;usingstatisticalmethodstatisticsobservationofShuanghuanglianxylenei

5、nducedmouseearswelling.MethodsChinesemedicine-Jinyinhua>LianqiaoandHuangqingwereextractedusingthemethodofBoilingwaterextractionThecapsuleswerepreparedbywetgranulating.andjdentifiedusingthemethodofTLCidentification.ThedisintegrationtimeofthecapsulewastestedusingDisintegrationapparatus.Theconten

6、tofHuangqinincompoundShuanghuangliancapsuleswasdeterminedbyusingthemethodofdualwavelengthspectrophotometry.TheresearchofpharmacodynamicsofcompoundusingthemouseearswellingmodelstudyonpharmacodynamicsofShuanghuangliancapsules.ResultsWefourgroupsgotfortycompoundShuanghuangliancapsulesthatconformt

7、othequalityrequirements.Andthepreparationofcapsuleshaveanti-inflammatoryeffect.ConclusionWithboilingwaterextract!onofcomponentsofChinesedrugs,thepreparedcompoundShuanghuanglianCapsuleonmicehaveanti-inflammatoryeffectandthebiggerthedosag