米索前列醇在妇产科临床的应用

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1、米索前列醇在妇产科临床的应用米索前列醇在妇产科临床的应用【摘要】米索前列醇是人工合成的前列腺素E1的衍生物，有多方面的临床用处,20世纪80年代早期米索前列醇最先用于消化性溃疡,80年代以后米索前列醇与米非司酗配伍用于抗早孕，可使完全流产率大大提高。近几年广泛应用于妇产科领域,如人工流产、上环、取环、诊断性刮宫、术前或口服阴道用药，起到扩张宫颈的作用，减少受术者的痛苦。米索前列醇用药中期引产,局部用药增加引产的效果，死胎引产成功率可达百分之百;用于足月妊娠诱发宫缩可缩短产程，预防剖宫产术后出血;治疗产后大出血

2、有明显的效果。米索前列醇的主耍作用是促进宫颈成熟，诱导分娩，减少产后出血，给药途径不同,产生的效果也不相同，口服吸收迅速,30mir）达到血药浓度高峰，血浆清除半衰期为1.5h,局部用药副作用小、吸收快，直接作用于宫颈。米索前列醇具有应用简便、效果可靠、易掌握、安全、副作用小、价格低的特点，适用于各级医院，尤其是基层医院,对减少产后出血的发生率，减低孕产妇死亡率，减少出血用量均有重要意义。【关键词】米索前列醇；早期流产；中期引产；死胎引产；产后出血预防ApplicationofMisoprostolincli

3、nicalGynaecologySHIXueyunXiqinWomenandchildren'sHealthClinic,300380,Tianjin[Abstract]MisoprostolisthederivativesofsynthesizedprostaglandinElandhasawiderangeofapplicationinclinics・Itisusedinthetreatmentofdigestiveulcerintheearly1980s,andthencombinedwithMifep

4、ristoneinthepreventionofearlypregnancyandabortioninthelate1980s・Inrecentyears,misoprostoliswidelyusedingynaecologyandobstetrics,suchasartificialabortion,putting-inandtaking-outofintrauterinedevice,diagnosticdilatationandcurettage,pre-operationalvaginalmedic

5、ationforthepurposeofcervixdilatationandpainrelieving・Inthecaseofmiddle-termpregnancytermination,localadministrationofmisoprostolcouldimprovetheefficacyoftermination,andensurethe100%terminationsuccessrate・Whenmisoprostolisusedinfull-termdelivery,itcanstimula

6、teUterineSpasm,shortendeliveryprocess,andpreventthehemorrhageaftercesareansection.Itcanalsohavegoodeffectsonthetreatmentofpostpartumhemorrhage・Inconclusion,themainfunctionofmisoprostolistoacceleratecervixmaturity,tofacilitatedelivery,toreducetheriskofpostpa

7、rtumhemorrhage.Theeffectsofmisoprostolcanbedifferentinaccordancewithdifferentmedicationmeans・Oralmedicationcouldleadtoquickabsorption,reachinghighestdrugconcentrationafter30minutes,andhaving15hoursofeliminationhalf-life・Localmedicationcanbedirectlyappliedto

8、cervix,producingsmallersideeffectsandquickabsorptionrate・Useofmisoprostolisconvenient,reliable,safe,inexpensiveandlowinsideeffects,andthereforeissuitableforapplicationingynaecologyandobstetrics・[Keywor