我们的一米阳光

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1、我们的一米阳光ThelperDrift主讲人：单晶莉一米阳光（5425、3325）CasestudyObjectiveToinvestigatetheeffectsofsteroidstherapyonTH1/TH2balanceinchildhoodprimarynephroticsyndrome(PNS).CasestudyMethodsDeterminationofThelperTH1andTH2cellspercentagein21ongoingcasesofPNSwithoutprednisonetherapy,15relapsecasesofPNSwithprednison

2、etherapyand9remissioncasesofPNSwithprednisonetherapybythreecolorflowcytometryfollowingwholebloodcellsculture,comparedwith10healthychildren.CasestudyResultsThepercentagesofTH1andTH2cellsinhealthychildrenwere(13.42±4.36)%and(2.53±1.97)%respectively.InthepatientswithongoingPNS,thepercentagesofTH1and

3、TH2cellsweresignificantlydecreased[(2.34±2.09)%and(1.02±0.96)%respectively].InthepatientswithrelapsePNS,thepercentageofTH1cellswasalsosignificantlydecreased[(1.20±0.91)%],butthepercentageofTH2cellswassignificantlyincreased[(7.65±4.53)%],andthedecreaseofTH1cellswasmoreobviousthaninonset.Intheremis

4、sionpatientswithPNS,theTH1andTH2cellspercentageswerenormal[(12.04±4.92)%and(2.81±2.65)%respectively].CasestudyResultsOntheotherhand,TH1/TH2ratiowas5.41±2.77inhealthychildren,normalintheremissionpatientswithPNS(4.25±2.12),lowinthepatientswithPNSinonset(2.43±2.65)andlowerinrelapsecasesthaninonset(0

5、.77±1.07).CasestudyConclusionThebeneficialeffectsofsteroidstherapycanbeexplainedbytheshiftfromtheTH2cellstoTH1cellsinchildrenwithprimarynephroticsyndrome,whichisprimarilycausedbytherelativelypredominantTH2cellsinvsTH1cells.ThebalanceofTh1＆Th2ThebalanceofTh1＆Th2isDistroyedTopicNormally,Th1/Th2isab

6、alancesystem.1ThebalanceshifttoTh1orTh2iscalledThelperdrift.2Itisassociatedwithmanydiseases.3ThebalanceofTh1＆Th2ThebalanceofTh1＆Th2IntroductionofThcellsWhatisThcelllooklike?IntroductionofThCellsClassificationofTh1/Th2cells1DifferentiationofThelpercells2BiologicalfunctionsofTh1/Th231、Classificatio

7、nofTh1/Th2cellsAccordingtothepresent/absentofCD4+/CD8+CD8+CytotoxicTlymphocytes(CTL)CD4+Thelpercells(Th)Th1Th2Cytokinestheysecret1986Mosmannmouse1991Romagnanihuman2、DifferentiationofThelpercellsCloneconversion克隆转化:when