妇癌考试解答

《妇癌考试解答》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、婦癌考試解答Date:Sep.11,20061.針對上皮性卵巢癌,術後第一線化學治療(不管期別),請寫出五種混合式化學治療處方(combinedchemotherapy),包括藥品,劑量,頻率,及療程cyclophosphamide(750mg/m2)+cisplatin(75mg/m2)(orcarboplatin)q3wx6coursescyclophosphamide(500mg/m2)+adriamycin(50mg/m2)+cisplatin(50mg/m2)q3wx6coursescarboplatin((AUC)of5-7.5)+paclitaxel(

2、175mg/m23-hrinfusion)q3wx6coursespaclitaxel(175mg/m2asa3-hourinfusion)+cisplatin(75mg/m2)q3wx6coursesdocetaxel(60-75mg/m21-hrinfusion)+carboplatin(AUCof5to6)q3wx6coursespaclitaxel(135mg/m2,IVfor24-hinfusionday1)+cisplatin(100mg/m2IP,day2)+paclitaxel(60mg/m2IP,day8(maxBSA2.0m2))q3wx6cour

3、ses2.針對下列婦癌疾病,最有效單一的化學藥物(singleactiveagent)為何?Uterinecerivcalcancer,SCC:CisplatinChoriocarcinoma:MTXUterineleiomyosarcoma:DoxorubicinUterineMMMT:Ifosfamide3.請問下列化療藥物各屬於何種類藥物？Etoposide:TopoisomeraseIIinhibitorEpirubicin:AntitumorantibioticsVincristin:VincaalkaloidCyclophosphamide:Alkylat

4、ingagentMethotrexate:Antimetabolics4.Cisplatinandpalcitaxel使用前應注意事項及其pre-medicationCisplatinHematologictoxicityNephrotoxicityCCr<50ml/min,contraindicationtoCisplatincarboplatinPrehydrationandposthydration,Diuretic(Lasix)GItoxicity(foremesis)Metoclopramide(primperan)Navoban(5H3serotonin

5、antagonist)NeurotoxicityPeripheralneuropathyVit.B(Hi-Bilox)4.Cisplatinandpalcitaxel使用前應注意事項及其pre-medicationPaclitaxelPaclitaxelCisplatin,CisplatinPaclitaxolGItoxicity(foremesis)prochloperazine(Novamin)HypersensitivityreactionCorticosteroids(Decadron)H1blocker(Benamine)H2blocker(Tagam

6、et)Dipjenhydramine(Allermin)Cardiotoxicity(arrhythmia,bradycardia):EKGmonitorNeurotoxicityPeripheralneuropathyVit.B(Hi-Bilox)5.ifosphamide是屬於何種類化學藥物?有哪兩種比較特殊的毒性?有何種化療保護劑(chemoprotectant),應如何使用?有那類婦癌疾病會應用到ifosphamide來治療(請至少寫出兩種)AlkylatingagentToxicityHemorrhagiccystitisIfosfamidesyndr

7、omeMesnaDose:60-120%ofifosphamidetotaldosage3-day:400mg/m2IV,15-min,4-hr,8-hr,for3days24-hr:Halfoftotalmesnadose:divide6dosesQ4HRemaininghalfdose:divide2dosesQ6Hcervicalcancer,ovariancancer,anduterinesarcoma6.請問Adriamycin和Bleomycine各屬於何種類藥物?兩者都有致命的毒性(dose-limitingsideeffect)其致命