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1、文献出处：BurkeP,RutherglenC.Towardsasingle-chip,implantableRFIDsystem:isasingle-cellradiopossible?[J].Biomedicalmicrodevices,2015,12(4):589-596・Towardsasingle-chip,implantableRFIDsystem:isasingle-cellradiopossible?PeterBurke;RutherglenCAbstractWepresentanoverviewofprogresstowardssingle-
2、chipRFIDsolutions.Todateheterogeneousintegrationhasbeenappropriatefornon・biologicalsystems.However,forin-vivosensorsandevendrugdeliverysystems,asmallformfactorisrequired.Wediscussfundamentallimitsonthesizeoftheformfactor,theeffectoftheantenna,andproposeaunifiedsingle-chipRFIDsolutio
3、nappropriateforabroadrangeofbiomedicalin-vivodeviceapplications,bothcurrentandfuture.FundamentalissuesregardingthepossibilityofsinglecellRFradiostointerfacewithbiologicalfunctionarediscussed.KeywordsSensorRFID1IntroductionWhenJamesClerkMaxwelldiscoveredthedisplacementcurrent,henceco
4、mpletingMaxwelfsequations,in1865,thestagewassetforthewirelesstransmissionofinformation.Itanother75yearsforthesemiconductorindustrytobebomandmatureintothefielditistoday.Themodicumanytimeanywhereaccesstoinformationisnowtakenforgranted.Today,everystudentineveryscienceandengineeringfiel
5、distaughtthefundamentalbasisofelectromagneticsandwirelesspropagationofsignalsandinformation.Thenext100yearswillseeasimilarrevolutionintheintegrationofinformationtechnologyandbiotechnology,alsocalledbiomedicalengineering.Thefieldoftelemedicine(e.g.scannedpatientrecords,emailorvirtual
6、officevisits,etc.)hasaccesstowirelesstechnologyandisbeginningtodeployandutilizethevast,lowcostinformationprocessingcapacity.Inthispaper,wewishtoaddressamoregeneralissue,thatofinterfacingthephysicalworldwiththebiologicalworld・Forinterrogationofbiologicalsystems,oneisgenerallyinterest
7、edinachemicalorphysicalquantity.Forachemicalquantity,typicalassaysdeterminethepresenceorconcentrationofaprotein,antibody,orsmallmoleculeanylate,thepresenceorconcentrationofaparticularDNAorRNA，orevenmoresubtlequantitiessuchasthephosphorylationstateofanenzyme.Ingeneral,thesebiomedical
8、lyrelevantphysicalq
