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1、<0.05),而与病人年龄无显著性差异(P>0.05)；肿瘤组织中VEGF表达与浸润深度、组织学分级有显著性差异(P<0.05),而与年龄、手术分期、淋巴结转移无关(P>0.05)(3)SPARCmRNA的表达在子宫内膜样腺癌中低于正常子宫内膜组织，与临床病理因素之间的表达存在显著性差界(P<0.05)；SPARC与SPARCmRNA在子宫内膜样腺癌组织有明显差异，呈显著正相关(-0.487,P=0.036)o(4)SPARC蛋白与VEGF蛋口之间的表达关系，在子宫内膜样腺癌中有明显差异，而且呈显著负相关(r=・0.213,P=0.001)(5)在子宫内膜样腺癌中，SPARC的表
2、达高分化腺癌高于中分化和低分化腺癌(P<0.05)研究结论：SPARC及其mRNA在子宫内膜样腺癌中低分化表达或缺失与肿瘤的分化程度及淋巴结转移密切相关，是子宫内膜样腺癌预后不良的独立预后因子。SPARC蛋白和VEGF蛋白表达水平在子宫内膜样腺癌组织中呈显著负相先考虑SPARC蛋白可能有抑制血管生成的条件，故此认为SPARC和VEGF蛋白之间相互抑制是治疗肿瘤疾病的新突破，对子宫内膜样腺癌的治疗有重要的科学依据。关键词：子宫内膜样腺癌，SPARC,VEGF,免疫组织化学，原位分子杂交ExpressionofSPARCandVEGFinendometrioidadenocarcin
3、omaanditsclinicopathologicalsignificanceAbstractBackgroundandobjective:Endometrialadenocarcinomaisoneofthewomenwithcommonmalignanttumorsisoneofthemostcommonendometrialadenocarcinoma,Accountsforabout60%ofendometrialcancers,75%caseshaveoccurredafterthemenopause,Only5%ofcasesoccurinwomenunderthe
4、ageof40,Mainlyin50-70-year-oldwoman.Inrecentyears,thistrendhasbeenincreasingyearbyyear・Inordertoimprovethequalityofsurvival,fromthelevelofmolecularbiologyevaluationtotestingtheprognosisofpatients,usingeffectivedrugappearsespeciallyimportant.Moreover,oneblockandtumorgenesisarecloselyrelatedtos
5、ignalingpathwaysandarethekeyroleinmoleculesendometrialcancerdetectionandtreatment.Andthesignalpathwayandtargetmoleculesandwhetherendometrialcancerhappensiscloselyrelatedtotheexactmoleculartargettherapyfoundation.RecentstudieshavefoundthatrichinhomocysteineacidProteinSPARC(SecretedProtein,Acid
6、icandRichinCysteine)andmalignanttumorinvasionandmetastasisareclosedrelated-ThisstudyinvestigatestheSPARCandSPARCmRNAinadenocarcinomaofendometriumtissuesandangiogenesisfactorsinVEGF,hopingitcanreachendometrialcarcinomamoleculartargettherapyandprovideatheoreticalbasis.Patientsandmethods:Patient
7、s:selectedfi-omJanuary2005toJune,2011inshanximedicaluniversityhospital,wetakethefirst134adenocarcinomaofendometriumsurgicalspecimensbothnotput,chemotherapyhistory.Thecontrolgroupis20casesofnormalendometrialorganization,tumortissueandnormaltis
