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ID:43711006
大小:1.31 MB
页数:24页
时间:2019-10-13
《第十一章维生素与辅酶生物化学与分子生物学教案》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、毛发脱落。视黄裁视蛋白骨架第一节维生素概论及脂溶性维生素、维生素A皮肤丁燥;缺乏:夜盲症、生长发育缓慢、过多:食欲不振、光敏感蛋白——视紫红质的合成步骤杈鬻红帐asa黄睡孑•金廣型现辭&4D耳一MAP1卜顺规黄胆k〒k饬生蕙A・軒驚烹絮A二、维生素D缺乏:佝偻病、软骨病、骨质疏松;过多:乏力、软组织钙化、循环呼吸衰竭。VIt25-Difei}tlroMpriuniinDs25-Hydro»p1undnD}<»«>Enpoldferol(vitaminDt)点击放人三、维生素EVifcNRii*E抗氧化、维持牛殖机能、促
2、进血红索合成。■四、维生素K凝血酶原的谷氨酸被竣基化后,与钙离子结合,有利丁•凝血卿原转化为凝血陋,促进凝血。GluNHCXVtewmiiEi!ViiaminK-dependentgliiiainvlcaiboxxlasv屮it”命.%UX«UIW
3、UaiMHU'SV>H)Ana4、IIcii,—c—co(rAcctolacutcsynthaseOOHIIICII,—C—C—COO・+Thiamine(vitaminBt)IPP^mlicuwAMPirprotonHCHThiaminepvropbosphaie(TPP)nsns—□—S—V°3IIoSHDjjpjuqiwnoiioiiirq.i^Jp47i(iqr)%-35U«U<>Sc>y^)CAnx5、,Leu乙酰乳酸合成酶反应机制1,c=o1cn9onCHOh(x:m111c=ohc:oiiClioUCOH1ffz、彳*vtTransketolase亠Jon+11Ify、l1IICXJl十1H(QIIk111HA7I11HCOH1IICOII1CILOPO^-I1(:H2()P()5~1CILOPO^1(:l"OP叶Xylulose-5-PRib<>so5-PGlyccraklehyde-3-PSedoheptulosc-7-PStep8CHnOH1■ch2oh1c=o1c=oCHOCHO1H(X:H1Transk6、etolase亠+1fVHOCH十11H(>OHl1HCOHi11ICOII11CH2OPC)^HCOH11ch2opo^1CH2OPOj"1CHoOPOi"Xylulose-5-PErythrose4-PGlyceraldehyde-3-PFructose^-P缺乏病:脚气病(干性、湿性、混合型)。二、维生素PP(Bs)和烟酰胺辅酶NkotuuimidcIIvdncieion.Nicolinamidc(reducedform)AMPNADP4con(aimaPonthis2-hydrox>l缺乏病:皮炎、腹泻、痴呆,7、即三。症状。RROxxfizctltftCROiw贰心gMWXZCMARHcmt»TAD^H>♦c・=x亠壬HCOIII1ICOHr>Ribi(o1AMP皮炎、口角炎等。Rr8、Scrniquinoncanion—j.IHII(gl)四.泛酸(B3)和辅酶A硫酯水解释放酰基在能量上比氧酯更有利,前者的△GO'为:-20.2kj/moL后者的△G0'为:-31.5kj/moloXII<)11JOa•S—c—ch3JNucleophilicV—attackOIIc—ch3□缺乏病为神经机能异常,极少见。0C(从一!?一•一⑴片■v—ZanatlaORSR1(2)不利阳発振綽氏更朋诉“養是険性的■聶且自1产11他欣負鹿于站蛊憲客屈常狀乘霰成轴牺醉负岸子制手播台竝愿客易亲镇五、维生素B6和磷酸毗哆醛9、、磷酸卩比哆胺抗结核药等引起的缺乏病为周围神经炎,小细胞低色素贫血。(EIO(XMTi-HIRcxxrI、<)=<:Tnins.iminati<>nRCOO's^Elimination(Mrt
4、IIcii,—c—co(rAcctolacutcsynthaseOOHIIICII,—C—C—COO・+Thiamine(vitaminBt)IPP^mlicuwAMPirprotonHCHThiaminepvropbosphaie(TPP)nsns—□—S—V°3IIoSHDjjpjuqiwnoiioiiirq.i^Jp47i(iqr)%-35U«U<>Sc>y^)CAnx5、,Leu乙酰乳酸合成酶反应机制1,c=o1cn9onCHOh(x:m111c=ohc:oiiClioUCOH1ffz、彳*vtTransketolase亠Jon+11Ify、l1IICXJl十1H(QIIk111HA7I11HCOH1IICOII1CILOPO^-I1(:H2()P()5~1CILOPO^1(:l"OP叶Xylulose-5-PRib<>so5-PGlyccraklehyde-3-PSedoheptulosc-7-PStep8CHnOH1■ch2oh1c=o1c=oCHOCHO1H(X:H1Transk6、etolase亠+1fVHOCH十11H(>OHl1HCOHi11ICOII11CH2OPC)^HCOH11ch2opo^1CH2OPOj"1CHoOPOi"Xylulose-5-PErythrose4-PGlyceraldehyde-3-PFructose^-P缺乏病:脚气病(干性、湿性、混合型)。二、维生素PP(Bs)和烟酰胺辅酶NkotuuimidcIIvdncieion.Nicolinamidc(reducedform)AMPNADP4con(aimaPonthis2-hydrox>l缺乏病:皮炎、腹泻、痴呆,7、即三。症状。RROxxfizctltftCROiw贰心gMWXZCMARHcmt»TAD^H>♦c・=x亠壬HCOIII1ICOHr>Ribi(o1AMP皮炎、口角炎等。Rr8、Scrniquinoncanion—j.IHII(gl)四.泛酸(B3)和辅酶A硫酯水解释放酰基在能量上比氧酯更有利,前者的△GO'为:-20.2kj/moL后者的△G0'为:-31.5kj/moloXII<)11JOa•S—c—ch3JNucleophilicV—attackOIIc—ch3□缺乏病为神经机能异常,极少见。0C(从一!?一•一⑴片■v—ZanatlaORSR1(2)不利阳発振綽氏更朋诉“養是険性的■聶且自1产11他欣負鹿于站蛊憲客屈常狀乘霰成轴牺醉负岸子制手播台竝愿客易亲镇五、维生素B6和磷酸毗哆醛9、、磷酸卩比哆胺抗结核药等引起的缺乏病为周围神经炎,小细胞低色素贫血。(EIO(XMTi-HIRcxxrI、<)=<:Tnins.iminati<>nRCOO's^Elimination(Mrt
5、,Leu乙酰乳酸合成酶反应机制1,c=o1cn9onCHOh(x:m111c=ohc:oiiClioUCOH1ffz、彳*vtTransketolase亠Jon+11Ify、l1IICXJl十1H(QIIk111HA7I11HCOH1IICOII1CILOPO^-I1(:H2()P()5~1CILOPO^1(:l"OP叶Xylulose-5-PRib<>so5-PGlyccraklehyde-3-PSedoheptulosc-7-PStep8CHnOH1■ch2oh1c=o1c=oCHOCHO1H(X:H1Transk
6、etolase亠+1fVHOCH十11H(>OHl1HCOHi11ICOII11CH2OPC)^HCOH11ch2opo^1CH2OPOj"1CHoOPOi"Xylulose-5-PErythrose4-PGlyceraldehyde-3-PFructose^-P缺乏病:脚气病(干性、湿性、混合型)。二、维生素PP(Bs)和烟酰胺辅酶NkotuuimidcIIvdncieion.Nicolinamidc(reducedform)AMPNADP4con(aimaPonthis2-hydrox>l缺乏病:皮炎、腹泻、痴呆,
7、即三。症状。RROxxfizctltftCROiw贰心gMWXZCMARHcmt»TAD^H>♦c・=x亠壬HCOIII1ICOHr>Ribi(o1AMP皮炎、口角炎等。Rr8、Scrniquinoncanion—j.IHII(gl)四.泛酸(B3)和辅酶A硫酯水解释放酰基在能量上比氧酯更有利,前者的△GO'为:-20.2kj/moL后者的△G0'为:-31.5kj/moloXII<)11JOa•S—c—ch3JNucleophilicV—attackOIIc—ch3□缺乏病为神经机能异常,极少见。0C(从一!?一•一⑴片■v—ZanatlaORSR1(2)不利阳発振綽氏更朋诉“養是険性的■聶且自1产11他欣負鹿于站蛊憲客屈常狀乘霰成轴牺醉负岸子制手播台竝愿客易亲镇五、维生素B6和磷酸毗哆醛9、、磷酸卩比哆胺抗结核药等引起的缺乏病为周围神经炎,小细胞低色素贫血。(EIO(XMTi-HIRcxxrI、<)=<:Tnins.iminati<>nRCOO's^Elimination(Mrt
8、Scrniquinoncanion—j.IHII(gl)四.泛酸(B3)和辅酶A硫酯水解释放酰基在能量上比氧酯更有利,前者的△GO'为:-20.2kj/moL后者的△G0'为:-31.5kj/moloXII<)11JOa•S—c—ch3JNucleophilicV—attackOIIc—ch3□缺乏病为神经机能异常,极少见。0C(从一!?一•一⑴片■v—ZanatlaORSR1(2)不利阳発振綽氏更朋诉“養是険性的■聶且自1产11他欣負鹿于站蛊憲客屈常狀乘霰成轴牺醉负岸子制手播台竝愿客易亲镇五、维生素B6和磷酸毗哆醛
9、、磷酸卩比哆胺抗结核药等引起的缺乏病为周围神经炎,小细胞低色素贫血。(EIO(XMTi-HIRcxxrI、<)=<:Tnins.iminati<>nRCOO's^Elimination(Mrt
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