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1、用卜环糊精作为粘结剂压片时，片剂的硬度和脆碎度可满足要求；以碳酸氢钠为发泡剂，可有效的促进片剂溶解，并对二氧化氯的产生起到促进作用；采用包衣技术可有效的增加片剂的稳定性，得到较好的效果。⑷依据《屮国药典2005年版》和卫生部2005版《消毒技术规范》对制备的亚氯酸钠■活化体系片剂的相关性能进行分析。分析得到：该片剂的平均片重为0.1548g,各片二氧化氯的平均含量为6.867mg（于水中反应30min后），片重差异在.4.65%〜6.91%之间，平均硬度和脆碎度分别为38.78N和0.56%,且平均崩解时限为655s；该片剂于水中
2、反应30min后，溶液的pH值为2.7,片剂的活化率达到77.71%；将该片剂于湿度为70%的54°C烘箱内放置14d后，二氧化氯的下降为8.77%,即有效贮存期达到1年。关键词：反应型，二氧化氯，包合物，片剂，性能分析ThePreparetionStudyonResponse-typeSolidChlorineDioxideDisinfectionPakedinSingal-IngredientABSTRACTChlorinedioxidegasissoactiveandunstablethatitisdifficulttoma
3、keintocompressedgas.Andtheliquidchlorinedioxideistoovolatiletoconcentrate.Sotheuseofchlorinedioxideislimited.Stabilizedchlorinedioxidesolutionhasmanydisadvantages,suchasthecontentofwateristoomuch,loweffectiveconstituentofchlorinedioxide,andneedingtoaddacidactivator,ec
4、t.Inthisarticle,wepresentedthepreparationandresearchofsolidchlorinedioxide.(1)Becausesodiumchloriteandsolidacidcouldreacttogeneratechlorinedioxide,somangyexperimentshavebeendoneconfirmthebestingredientsoftheactivatesystem.Intheresearch,thedifferentmassratiosofsodiumch
5、loriteandactivesystemhavebeendiscussedbyactivateeffectiveness.Theactivesystemwasconstitutedbyacidifier,activator,passivator.Atlast,Wehaveobtained:①ItcouldgetsatisfactoryeffectwhenadoptacidXandacidYasacidificationagent,andthemassratiosofthetwoacidswithsodiumchloratewer
6、eboth5:3.②InthesystemofacidX,whenusingactivatorAasactivator,theconversionofsodiumchloratewasthelargest,andthemassratioofsodiumchloritewithactivatorAwas1:1•③InthesystemofacidY，activatorBhadthebesteffectofactivation,andthebesteffecthappenswhenthequalityratiowas5:3.©Thes
7、tabilityofthesystemcouldgetcertainsecuritywhenusingmagnesiumsulfateandcalciumchlorideaspassivator.(2)Becauseofthep-CDhascavitystructure,utilizedthischaracteristicandstudiedtheinclusionprocessof卩・CDandsodiumchlorite.Taked卩・CDasthesubjectofinclusionprocess,andsodiumchlo
8、rateastheobjectinclusionprocess,observeseveralfactorswhichcouldinfluencetheeffectofinclusionprocess,suchasmolarratio,reactio
