我国南北血压差异及其膳食因素的作用

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1、我国南北血压差异及其膳食因素的作用——营养与血压的国际合作研究(INTERMAPStudy)中国医学科学院心血管病研究所阜外心血管病医院赵连成周北凡武阳丰INTERnationalcollaborativestudyonMAcronutrientsandBloodpressure(FinanciallysupportedbyNHLBI)INTERMAP研究简介INTERMAP研究背景一般人群中，人群血压水平从中年开始明显增加；而在一些特殊人群中，人群血压水平没有随年龄增加或增加不明显；移民流行病学研究提示，人群血压

2、水平以及血压随年龄增加的现象与生活方式有关；已有的研究提示生活方式如膳食因素(BMI、钠、钾、饮酒等）因素与血压有关；缺乏高质量的、大规模、不同人群背景的研究；INTERMAP主要研究目的探讨多种膳食营养因素与血压的关系。INTERMAP研究特点横断面研究；4个国家，17个研究人群；中年人群，40－59岁，共4680人；高质量的研究方法，包括统一、高质量的膳食调查方法；具有可比性的食物成分表评估营养素的摄入量。INTERMAPFieldCenters:China营养与血压关系的国际合作研究...BeijingShanx

3、iGuangxiINTERMAPFieldCenters:JapanSapporo....ToyamaAitoTownWakayamaINTERMAPCenters:UnitedKingdom...BelfastBirminghamLondon(CoordinatingCenter)MinneapolisChicagoINTERMAPFieldCenters:UnitedStatesPittsburghBaltimoreJacksonHoustonCorpusChristiHonolulu........Backgro

4、undBloodpressure(BP)andprevalenceofhighBParegreaterfornorthernthanforsouthernChinese.AlthoughafewstudiessuggestthatheavierbodymassandhighersaltintakeinthenortharerelatedtotheseBPdifferences,theseunfavorablecharacteristicsonlypartiallyexplainedthenorth-southBPdif

5、ferences.PurposeToevaluatemultipledietaryfactorsindeterminingNorth-SouthBPdifferencesinChina.StudyPopulationTherearethreeChineseruralsamples,twofromtheNorth(PingguConuty,Beijing,andYuCounty,Shanxi)andonefromtheSouth(WumingCounty,Guangxi);Population-basedsample;2

6、60persons(1perfamily)wasrandomlyselectedfromeachtargetpopulation,stratifiedbygender10-yearagegroup.MeasurementsFieldworkwasconductedin1997-1998.Eachparticipantattendedthelocalcenteronfouroccasions–twopairsofconsecutivedaysabout3-6weeksapart.Bloodpressurewasmeasu

7、redtwiceateachvisitwitharandomzerosphygmomanometer.Heightandweightwithoutshoesorheavyclothesweremeasuredatthefirstandthirdvisits.DietaryMeasurementsDietarydatawerecollectedateachofthefourvisitsbystandardized24-hourdietaryrecalls.Nutrientswerecalculatedwithuseofa

8、nextensivedatabase,derivedfromtheChinesenationalfoodtableandenhancedbytheNutritionCoordinatingCenter(NCC),UniversityofMinnesota.Twotimed24-hoururinespecimenswerecolle