糖尿病肾病患者血清中timp1水平的变化及意义

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1、糖尿病肾病患者血清中timpl水平的变化及意义青岛大学硕士学位论文姓名：余正元申请学位级别：硕士专业：内科学（肾病）20030901指导教师：刘丽秋中文摘要糖尿病肾病息者血清屮TIMP一1水平的变化及意义目的观察金属蛋白酶组织抑制因子一1TIMP.1在糖尿病肾病不同阶段的变化规律，进而探讨TIMPo1在糖尿病肾病发生、发展过程屮的作用。含量，采用方差分析和q检验比较各组TTMP.1水平的差异性；TIMP一1在不同性别间的差异分析用t检验，TIMP.1水平与年龄的关系采用直线性相关分析和t检验。1259,05±

2、21病肾病肾功能衰竭组2131组及糖尿病肾功能衰竭组血清中TIMP.1水平比正常对照组显著增高P均0.01。临床期糖尿病肾病组比糖尿病组、糖尿病肾病肾功能衰竭组比临床期性别间的差异无统计学意义。在DM组和DNF组，TIMP.1水平与年龄正相著性。结论随着糖尿病肾病的病情进展，血清中TIMP.1水平逐渐增高，提示TIMP。1可能参与了糖尿病患者动脉硬化、动脉粥样斑块的形成及高血压的重塑、肾小球硬化，在糖尿病肾病发生、发展过程中起着重要作用。关键词：金属蛋口酶组织抑制因子一1TIMP-1糖尿病肾病动脉硬化肾小球硬

3、化酶联免疫吸附实验ELIsA糖尿病研究生：余正元肾病内科导师；刘丽秋墓茎梨要MPSTUDYONSERUMLEVEkSOFTIBET10NEPHROPATHYPAT1ENTSWITHDIAABSTRACTcrHmlcvelsoftissucinhibitorofnictaectveTothesObjinvestigatewithdiabet-diffcrcntclinicalofstagespatients1Ioproteinase一1TIMP一1intheroleofT!MP??tintheandicdcvc

4、lopmcntprogr—nephropathy,toexploreessionofdiabeticnephropathy.sweretoconductthisMethodEightypeeplesampleddiabeticnonnalcontrOlIIgroupNC,n20,typerenalfailureofdiabeticofdiabcticstagestagenephropathyDM,n320andectsfromallconcentrationsofTTMP一1subjnephropathyDN

5、F,n20.Serumweredetectedbyenzyme-linkedanalyseTTMP~llevelsbetweenandbetweengroupsthedifferenceofstatistical!)^test・ThesexwithofanalysisofTIMP??llevelandwerecheckedwithcorrelationanalysisagerelativityandt-test.97±1ResaTtSerumleveTsofTTMP-1were825259.05and2137

6、.34ng/ml，1in31:42±218.47NC,ng/ml.1508.31±282.57ng/mI4-441.25nglmlofTIMP—linwithDM,andDNFDNDNbDNresp5ectivelyoLevelspatientsandDNFweremeregr-significantlyT1MPllevelwith1•PatientswithDNhadhi-oupP0.0highercomparedDMwithDNFhadelevatedthanthoseianormalcontrOlsig

7、nificantlypatientsP0.05.Inaddition，patientswasnostati??TTMP—llevelwithDNghercomparedpatientsP0.Oil.TheretheconcentrationsofsticalbetweensignificancesexP005,butwithcoefficientinDManclDNFgroups,theTIMP-lwereassociatedagesofcorrc1ationwas0.4866P0.05and萎奎塑墨stic

8、aldifferencebetweenthecoefficientofcowasnostatiapparcntrrel.a.ti—onsnSertlmlevelSOfTIMP??lWereraduallincreCOacIasiOasiWiththeressiOnofdiabeticnecrcsuItSProgPhT^OPathY.ThngeStethatTIMP—lmcOntributetOVas