药代动力学期末复习-本书数学符号注释

《药代动力学期末复习-本书数学符号注释》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、—、本书数学符号注释(Glossary)u药物体内分布的表观一级速度常数(Apparentfirst-orderdistributionrateconstantforadrugthatconfersuponthebodythecharacteristicsofamulticompartentmodel)3多房室模型描述药物消除的表观一级速度常数(Apparentfirst-ordereliminationrateconstantforadrugthatconfersuponthebodythecharacteristicsofamulticompar

2、tentmodel,obtainedfromtheterminalslopeofasemilogarithmicplotofdrugconcentrationintheplasmaversustime)t给药间隔时间(Dosinginterval)A吸收表面积(Theareaofabsorption)AUC血药浓度■时间曲线下面积(Theareaunderthedrugconcentrationintheplasmaversustimecurve)C时间r的血药浓度(Drugconcentrationintheplasmaattimet)dC/dr血

3、药浓度的变化率(Rateofchangeofdrugconcentrationintheplasma)J；Cd/血药浓度■时间曲线下总面积(Totalareaunderthedrugconcentrationintheplasmaversustimecurve)f^Cdr血药浓度•时间曲线下时间从零到/的面积(AreaunderthedrugconcentrationintheplasmaversustimecurvefromtimezerotoT)C(ly稳态时“平均”血药浓度(Averagedrugconcentrationintheplasma

4、atsteadystateuponmultipledosing)Cmax一次给药后'峰血药浓度(Maximumdrugconcentrationintheplasmafollowingadministrationofasingledose)Cn经n次给药，间隔期间任一时间/的血药浓度(drugconcentrationintheplasmaatanytimetduringthen-thdosinginterval)Css零级过程输液后稳态时的血药浓度(drugconcentrationintheplasmaatsteadystatefollowing

5、zero-orderinfusion)Co静注后瞬间的药物浓度(drugconcentrationintheplasmaimmediatelyfollowingintravenousinjection)(Cj)max多次给药首次的最高血药浓度(Maximumdrugconcentrationintheplasmaafterthefirstofaseriesofrepetitivedoses)(Ci)min多次给药首次的最低血药浓度(Minimumdrugconcentrationintheplasmaafterthefirstofaseriesofr

6、epetitivedoses)J多次给药达稳态时某一给药间隔的任一时刻的血药浓度(Drugconcentrationintheplasmaatanytimetduringadosingintervalatsteadystateuponmultipledosing)JJC^dr稳态时某一给药间隔期内血药浓度■时间曲线下面积(Areaunderthedrugconcentrationversustimecurveduringacompletedosingintervalatsteadystateuponmultipledosing)(CTO)max稳态时

7、某一给药间隔期间最高血药浓度(Maximumconcentrationofdrugintheplasmaduringadosingintervalatsteadystateuponmultipledosing)(CJmin稳态时某—给药间隔期间最小血药浓度(Minimumconcentrationofdrugintheplasmaduringadosingintervalatsteadystateuponmultipledosing)Cl总清除率(Totalclearance)Cl,-肾清除率(Renalclearance)C/g-肌酉干清除率(Cr

8、eatinineclearance)F吸收率的通称，即剂量吸收的分数值(Thisisarathergener