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1、·20·ChineseJournalofInformationonTCMNov.2010Vol.17No.11·实验研究·化积止痛巴布剂穴位贴敷配合益气化积方内服对H22荷瘤小鼠的抑瘤作用111112王兰英,黄邦荣,杨佳华,倪红,展锐,蔺兴遥(1.甘肃省中医院肿瘤科,甘肃兰州730050；2.甘肃中医学院科研实验中心,甘肃兰州730000)摘要：目的探究化积止痛巴布剂穴位贴敷配合益气化积方内服对H22荷瘤小鼠的抑瘤作用及其作用机理。方法选合格的SPF级昆明种雌性小鼠50只,分为5组,即空白组、模型组、药物组、穴贴组、药物＋穴贴组。接种瘤株
2、,各实验组分别给予相应治疗。14d后,观察不同处理方法对H22荷瘤小鼠瘤质量、抑瘤率的影响。结果药物＋穴贴组和药物组的瘤质量与模型组比较差异具有统计学意义(P＜0.01)；药物组、穴贴组、药物＋穴贴组的抑瘤率分别为22.4%、11.2%、41.1%。结论化积止痛巴布剂穴位贴敷配合益气化积方内服均能减小瘤质量,对H22荷瘤小鼠肿瘤有明显抑制作用,抗肿瘤的机理可能是多环节的。关键词：化积止痛巴布剂；穴位贴敷；益气化积方；药效学；荷瘤小鼠DOI：10.3969/j.issn.1005-5304.2010.11.008中图分类号：R285.5文献
3、标识码：A文章编号：1005-5304(2010)11-0020-02AntitumorEffectofExternalAnalgesicNavelAcupointStickingCataplasmandInternalYiqi-doseonH22Tumor-bearingMiceWANGLan-ying,HUANGBang-rong,YANGJia-hua,etal(OncologyDepartment,GansuProvinceHospitalofTCM,Lanzhou730050,China)Abstract：ObjectiveTo
4、observeandexploretheantitumoreffectofcollectiveuseofexternalAnalgesicacupointstickingCataplasmandinternalYiqi-doseontheH22tumor-bearingmice,andanalyzeitsunderlyingmechanismsupportingforclinicaltrial.MethodsFiftyhealthySPFlevelKunmingfemalemicewereevenlyrandomizedinto5grou
5、ps：blankgroup,modelgroup,cataplasmgroup,dosegroup,collectiveusegroup.Aftertumorvaccinationand14-daytreatment,thetumorqualityandinhibitionratioofeachgroupwereobservedandcompared.ResultsTherewassignificantdifferenceintumorqualityofcollectiveusegroupanddosegroupcomparedwithm
6、odelgroup(P＜0.01).Thetumorinhibitionratioofdosegroup,cataplasmgroupandcollectiveusegroupwas22.4%,11.2%and41.1%respectively.ConclusionCollectiveuseofexternalAnalgesicacupointstickingCataplasmandinternalYiqi-dosecandecreasethequalityoftumorandinhibitthetumorgrowthofH22tumor
7、-bearingmice.Itsantitumormechanismcouldbeinmanylevels.Keywords：AnalgesicCataplasm；acupointsticking；Yiqi-dose；pharmacodynamics；tumor-bearingmice我们将临床疗效确切、治疗癌症的外敷经验方制成化积止痛巴布剂是以经验方为基础,由雄黄、青黛、皮硝、乳香、没痛巴布剂穴位贴敷,配合中药益气化积方内服,根据中药调节药、莪术、芫花、蟾蜍等组成,按膏药与基质的比例,加入膏料、机体免疫力及止痛的机理,了解中药和经络穴位
8、的双重调控对挥发油、冰片乙醇溶液,应用特殊工艺制成,每1g膏药含原药癌肿的抑瘤作用,探讨其可能的作用机制,为临床提供实验依材约0.12g,每贴直径10mm,厚度1.5mm,重约0.4g,穴位贴
