资源描述：
《58例艾滋病合并马尔尼菲青霉菌病病人临床特征分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、58例艾滋病合并马尔尼菲青霉菌病病人临床特征分析陈媛媛刘旭辉侯明杰原海珍王章云王延丽辛宁波赵清霞郑州市第六人民医院感染一科X关注成功！加关注后您将方便地在我的关注中得到本文献的被引频次变化的通知！·新浪微博·腾讯微博·人人网·开心网·豆瓣网·网易微博摘 要：目的分析艾滋病(AIDS)合并马尔尼菲青霉菌病病人的临床特征。方法采用回顾性分析方法,对2014年1月至2016年12月出院的58例AIDS合并马尔尼菲青霉菌病病人的临床表现、辅助检查和实验室资料进行分析。结果58例病人中发热占94.8%,咳嗽占70.7%,特征性皮疹占46.6%
2、,腹痛占39.7%,脾大占55.2%,腹腔淋巴结肿大占51.7%,贫血占81.0%。CD4+T淋巴细胞(简称CD4细胞)计数中位数为10个/μL,<50个/μL的占85.7%。血培养马尔尼菲青霉菌阳性47例,阳性率81.0%,其他组织、体液培养和病理阳性11例,占19.0%。GM试验阳性91.7%(44/48),G试验阳性72.0%。两性霉素B联合伊曲康唑序贯治疗占79.3%。好转出院49例(84.5%),恶化出院9例(15.5%)。结论AIDS合并马尔尼菲青霉菌病好发于CD4细胞<50个/μL的病人,临床表现复杂多样。诊断依靠病原菌的培
3、养及组织病理,抗真菌治疗效果好。关键词：艾滋病;马尔尼菲青霉菌;临床特征;作者简介：陈媛媛(1975-),女,浙江省鄞州区人,副主任医师,硕士,从事艾滋病临床诊疗研究。Email:cyy1805@126.com作者简介：赵清霞,主任医师,Email:zhqx666@163.com基金：郑州市科技攻关项目(141PPTGG318)Clinicalanalysisof58AIDSpatientswithpenicilliosismarneffeiCHENYuanyuanLIUXuhuiHOUMingjieYUANHaizhenWANGZhan
4、gyunWANGYanliXINNingboZHAOQingxiaDepartmentofInfectiousDiseases,No.SixthPeople'sHospitalofZhengzhouCity;Abstract：ObjectiveToinvestigatethecharacteristicsofAIDSpatientswithpenicilliosismarneffei(PSM).MethodsTheclinicaldataof58AIDSpatientswithPSMwereanalyzed,whoweretreatedi
5、nourhospitalbetweenJanuary2014andDecember2016.ResultsThecommonsymptomsincludedfever(94.8%),cough(70.7%),characteristicskinlesions(36.6%),bellyache(39.7%),splenomegaly(55.2%),enlargementofabdominallymphnodes(51.7%),andanemia(81.0%).ThemedianofCD4+Tlymphocytewas10cell/μl,an
6、dthepatientswhoseCD4+Tlymphocyteswerelessthan50cell/μlaccountedfor85.7%.Positiverateofpenicilliummarneffeiwas81.0%viabloodcultureand19.0%viaotherbodyfluidsandtissuescultureandtissuebiopsy.Thepositiveofplasma(1-3)-β-D-gluantestandserumgalactomannanwere91.7%and72.0%.Amphote
7、rycinBcombinedwithitraconazolesequencetherapywas79.3%.49patients(84.5%)wereimprovedanddischarged,and9patients(15.5%)weredischargedwithoutrecovery.ConclusionAIDSwithpenicilliosismarneffeiiscommonlyseenintheAIDSpatientswhoseCD4+Tlymphocytesarelessthan50/μl,andtheirclinicalm
8、anifestationsarecomplex.Diagnosisdependsonpathogenicbacteriacultureandhistopathology.Antifungalt
