资源描述：
《Current Understanding on EGFR英文学习材料》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、ReviewGenes&Cancer4(11-12)427–446CurrentUnderstandingonEGFR©TheAuthor(s)2013Reprintsandpermissions:andWnt/β-CateninSignalinginsagepub.com/journalsPermissions.navDOI:10.1177/1947601913503341GliomaandTheirPossibleCrosstalkganc.sagepub.com1,*1,*1IndranilPaul,SeemanaBhattacharya,AnirbanCh
2、atterjee,1andMrinalK.GhoshSubmitted9-Apr-2013;accepted31-Jul-2013AbstractGlioblastomamultiformes(GBMs)areextensivelyheterogeneousatbothcellularandmolecularlevels.Currenttherapeuticstrategiesincludetargetingofkeysignalingmoleculesusingpharmacologicalinhibitorsincombinationwithgenotoxic
3、agentssuchastemozolomide.Inspiteofallefforts,theprognosisofgliomapatientsremainsdismal.Therefore,aproperunderstandingofindividualmolecularpathwaysresponsiblefortheprogressionofGBMisnecessary.Theepidermalgrowthfactorreceptor(EGFR)pathwayisprobablythemostsignificantsignalingpathwayclini
4、callyimplicatedinglioma.Notsurprisingly,anti-EGFRtherapiesmostlyprevailfortherapeuticpurposes.TheWnt/β-cateninpathwayiswellimplicatedinmultipletumors;however,itsroleingliomahasonlyrecentlystartedtoemerge.Wegiveaconciseaccountofthecurrentunderstandingoftheroleofboththesepathwaysingliom
5、a.Last,takingevidencesfromalimitedliterature,weoutlineanumberofpointswherethesepathwaysintersecteachotherandputforwardthepossibilityofcombinatoriallytargetingthemfortreatmentofglioma.Keywordsglioma,signaling,EGFR,β-catenin,crosstalkIntroductionPI3K(phosphatidylinositide3kinase)/Aktpat
6、hwaysandinactivationofthep53/Rbpathwaystobeimportantcon-Malignanciesofthecentralnervoussystemaregenerallytributorsforgliomadevelopment.Thesealterationsfacili-classifiedasmeningiomas,oligodendrogliomas,andastro-tatecellsurvival,proliferation,andmigrationandthusare2cytomas.Astrocytomasa
7、refurthersubdividedintopilo-crucialfortumorigenesis.Anotherimportantfactorthatcytic(gradeI),diffuse(gradeII),anaplastic(gradeIII),andhasrecentlyemergedtobeasignificantdeterminantofgli-glioblastomamultiforme(GBM;gradeIV).GBMrepre-omainitiationandprogressionisthecanonicalWnt/β-sentsthem
8、ostco
