资源描述：
《口服高氧液抗小鼠运动性疲劳的作用及机制研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、口服高氧液抗小鼠运动性疲劳的作用及机制研究刘春然I,张国良I,徐礼鲜I(第四军医大学J口腔医院麻醉科，陕西西安710032)AexperimentalstudyofhyperoxiasolutiontakenorallyonfatigueanditsmechanisminmiceinducedbyexerciseLIUChun-Ran1,ZHANGGuo-Liang1fXULi-Xian1departmentofAnesthesiology,CollegeofStomatology,FourthMilitaryMedicalUniversity,Xi'
2、an710032,China[Abstract]AIM：Toinvestigatetheantifatigueeffectofhyperoxiasolution(HO)anditsmechanism.METHODS：Themiceweredividedrandomlyintotwogroups:controlgroup(Cgroup),hyperoxiasolutiongroup(HOgroup).Theneachgroupwasdividedintothreesmallergroupsbydose,whichwereinfusedwithbalanc
3、edsaltsolutionorHOat0.15ml、0.25mland0.5mlperlOg.Afterthemicewereinfusedintragastricly,thecontentsofmuscleglucogen,lacticacidandmalondialdehyde,thegeneralabilityofantioxidationandtheenergyofadenosinetriphosphateenzymeweredeterminedinstantlyandafterswimming30minutewhiletheywereobs
4、ervedaboutcommonstate.RESULTS:Hyperoxiasolutiongroupswammoreactivelyandsankfewerthancontrolgroup.Thecontentsoflacticacidofhyperoxiasolutiongroup(&91〜10.42±L41mmol/L)weresmallersignificantlythanthoseofcontrolgroup(11.91〜12.01土1.34mmol/L,P<0.05);thecontentofmuscleglucogenofhyperox
5、iasolutiongroup(1.57〜2.07±0・15mg/g)wasbiggerdistinctlythanthoseofcontrolgroup(1.03±0」4mg/g,P<0.05);theactivityofadenosinetriphosphateenzymeofhyperoxiasolutiongroup(1.10〜l・49±0.12
6、imolPi/mgprot/hour)increasedmorethanthoseofcontrolgroup(0.79~1.08±0.13
7、imolPi/mgprot/hour,P<0.05);th
8、econtentofmalondialdehydeofhyperoxiasolutiongroup(17.74〜1&93±1・26nmol/mgprot)weresmallersignificantlythanthoseofcontrolgroup(20.50~20.55±1.24nmol/mgprot,P<0.05);thegeneralabilityofantioxidationofhyperoxiasolutiongroup(175.87-202.87±22.OOnkat/mgprot)increasedmorethanthoseofcontro
9、lgroup(134.53-137.36±16.OOnkat/mgprot,P<0.05).CONCLUSION:HOcanincreasemovingcapabilityofmicesignificantly,andhasantifatiqueeffect.ThemechanismmaybethatHOcanincreasethesupplyofoxygenandhasanti-lipidperoxidationeffect・[Keywords]hyperoxiasolution;fatigue;lacticacid;muscleglucogen;t
10、heactivityofadenosinetriphosphateenzyme;malondi
