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1、ApplicationofPorousScavengersforHighThroughputPurificationCorySzafranski,QunjieWang,JosephJ.Kirkland,TimothyLangloisAgilentTechnologiesInc.LorinA.ThompsonDuPontPharmaceuticalsAPPLICATIONOFPOROUSSCAVENGERSFORHIGHTHROUGHPUTPURIFICATIONCorySzafranski,QunjieWang,JosephJ.KirklandandTimoth
2、yLanglois,AgilentTechnologiesInc.,2850CentervilleRoad,Wilmington,DE19808;LorinA.Thompson,DuPontPharmaceuticals,Wilmington,DE19880-0500ABSTRACTToovercomepracticaldifficultiesrelatedtogel-typepolystyrene-basedscavengers,i.e.largewetvolume,significantswelling,solventincompatibilities,an
3、dlowflow-throughefficiencies,wehaverecentlydevelopedsilicaandmacroporouspolymerbasedscavengers(CombiZorb).Thispresentationdescribestheadvantagesandusefulnessofthesescavengers,andapplicationsoftheminvariousreactionprotocols.IntroductionSolidscavengersareincreasinglyusedinparallelorgan
4、icsynthesistoremoveexcessreactantsorby-products.However,mostscavengersarebasedongel-typepoly-styrene,whichfeatures:1)veryhighswellinginsomesolvents-cannotbepre-packedandstoredinacartridgeorcolumnformat;2)necessityofswelling-narrowrangeofcompatiblesolvents.Newmacroporousscavengers-Com
5、biZorbhasbeendevelopedbasedonultra-pure,sphericalsilicaandlowswellingmacroporouspolystyrene/DVB,toovercomethesedrawbacks.MacroporousScavengersBasedonultra-pure,sphericalsilica:S-Monoamine(NH2),S-Triamine(NH,NH2),S-TertiaryAmine,S-SulfonicAcid,S-Aldehyde,S-Epoxide,S-Mercaptan,S-Diphen
6、ylethylphosphine.Basedonlow-swellingmacroporouspolystyrene/DVB:MP-Isocyanate,MP-Aldehyde,MP-Mercaptan,MP-Trisamine(NH,NH2),MP-Piperidinomethyl,MP-SulfonylHydrazide(-NHNH2),MP-SulfonylChlorideFeaturesandAdvantages(vs.gel-typepolystyrenebasedscavengers)Silica-based:Ultrapuresilica-noin
7、terferencewithreactions.Sphericalsilica-easytohandle,goodflow-throughproperties.No-swelling,highdensity-largeramountforavailablevolume;possibleincorporationintodifferentformats(membrane,column).Porousstructure-solventindependent,goodmasstransferofreactants.Low-swellingmacroporouspoly
8、styrene/DVB-
