药物制剂专业论文

《药物制剂专业论文》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、药物制剂专业论文药物制剂专业论文摘要风痛宁片治疗风湿性关节炎和类风湿性关节炎，具有祛风燥湿，散寒活血，舒筋止痛的功效，应用范围非常广泛。麻黄具有平喘止咳生理活性，为药品中主要成分之一。麻黄的主要活性成分是麻黄碱。测定麻黄碱的方法多有报道，风痛宁片为复方制剂，药味多，其它组分干扰大，采用水蒸气蒸馏方法提取麻黄碱。方法是在强碱条件下将风痛宁片中麻黄碱分离，与碳酸钠、过碘酸钠反应生成苯甲醛，在242nm下利用紫外分光光度法进行含量测定。结果显示：方法可行，在2.5～10μg/ml范围线性关系良好，A=0.0618C+0.0594(r=0.9994，n=5)，麻黄碱测定

2、的平均回收率为98.63%，RSD为1.07%（n=5），不同批号的风痛宁片中麻黄碱含量差异不明显，含量比较稳定。在强光照射下,麻黄碱含量不稳定；在低温、高温情况下，含量较稳定。选择适宜的光照和温度对保持中药制剂的稳定性提供有力的数据。关键词：风痛宁片麻黄碱稳定性分光光度法药物制剂专业论文AbstractFengtongningtabletiswidelyusedforthetreatmentofrheumatoidarthritisandrheumatoidarthritis,withawiderangeofapplications,suchasgetting

3、ridofcoldanddampness,promotingthecirculationofblood,dispellingcold,stretchingligamentandanalgesic.Ephedra,asoneofthemaincontentinthemedicine,hasthephysicalactivityofeaseasthmaandcough.Ephedrineisthemainactiveingredientofephedra.Alargenumberofmethodsforthedeterminationofephedrinehaveb

4、eenalredyreported.Asacompoundpreparation,theingredientsoffengtongningtabletisnotasigle,theinterferenceofothercomponentscan′tbeneglected.weextracttheephedrinewiththemethodofsteamdistillation.First,intheconditionofstrongalkaline,separatingtheephedrineformfengtongningtablet,changetheeph

5、edrinetobenzaldehydeafterreactingwithsodiumcarbonateandsodiumiodide,atthewavelengthof242nm,thesamplesweredeterminedbyUVspectrophotometricmethod.Thelinearcurveswasfinebetweentheconcentrationrange2.5-10μg/ml(r=0.9994,n=5).Ephedrineaveragerecoverywas98.63%,RSDis1.07%(n=5).Differencesint

6、hecontentofephedrinebetweendifferentbatchesoffengtongningtabletisnotobvious,thecontentofephedrineisrelativelystable.Inthelightofhighintensity,thecontentofephedrineisinstable,butinthecaseoflowtamperatureandhightamperature,thecontentofephedrineismorestable.Wecanconcludethat:itispowerfu

7、ldataforthestabilityofchinesemedicinetoselectappropriateintensityoflightandtemperature.Keywords:FengtongningtabletEphedrineStabilitySpectrophotometry-药物制剂专业论文目录摘要...........................................................IAbstract......................................................

8、..II1绪论.....