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1、CurrPathobiolRep(2015)3:183–192DOI10.1007/s40139-015-0077-zMATRIXPATHOBIOLOGY(YOUHUALIU,SECTIONEDITOR)KeyFibrogenicSignaling11WeichunHe•ChunsunDaiPublishedonline:5April2015ÓTheAuthor(s)2015.ThisarticleispublishedwithopenaccessatSpringerlink.comAbstractFibrosisisdefine
2、dasanexcessiveaccumula-mayresultfromdiversecauses,itisgenerallythoughtthattionofextracellularmatrixcomponentsthatleadtotheaninitialinjuryactivatesarepairprocessthataimstore-destructionoforganarchitectureandimpairmentoforganstoretheoriginaltissuestructure,andthatafail
3、uretofunction.Moreover,fibrosisisanintricateprocessat-delicatelyregulatethisprocessresultsinsustainedfibrob-tributabletoavarietyofinterlacedfibrogenicsignalsandlastactivation,matrixdeposition,andtissuedevastationintrinsicmechanismsofactivationofmyofibroblasts.Be-[2].Fibr
4、osisispartofprogressivelychronicdiseasesiningthedominantmatrix-producingcellsinorganfibrosis,parenchymalorgansthroughoutthebody,andthefibroticmyofibroblastsmaybedifferentiatedfromvarioustypesofprocessplaysanessentialroleinthedeteriorationoftheseprecursorcells.Identificat
5、ionofthesignalpathwaysthatorgans[1••,3••,4].Feweffectivetherapiestohalttissueplayakeyroleinthepathogenesisoffibroticdiseasesmayfibrosis,ortoreverseit,areavailableinclinicalpracticesuggestpotentialtherapeutictargets.Here,weemphasize[5••].Consequently,itisimportanttothor
6、oughlyunder-severalintracellularsignalingpathwaysthatcontrolthestandthecellularandmolecularmechanismsoffibroge-activationofmyofibroblastsandmatrixproduction.nesis,notonlytoacquirenovelinsightsintothepathogenesisofthefibroticprocess,butalsotofurtherKeywordsFibrosisSmad
7、Mitogen-activatedproteinexploitefficientstrategiestotreatpatientswithfibrotickinasePhosphoinositide3kinaseWnt/b-cateninSonicdisorders.hedgehogFibrogenesisisadynamicandprogressiveprocessinwhichnonresolvinginflammationfollowingapersistentinjurysetsthestageforfibrosisand
8、triggerstheactivationIntroductionofmatrix-producingmyofibroblastsdifferentiatedfromavarietyofprecursorcelltypesthroughdifferentmecha
