Development of magnesium calciumphosphate biocement for boneregeneration镁钙的开发 磷肥生物发电

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1、Downloadedfromhttp://rsif.royalsocietypublishing.org/onAugust12,2018J.R.Soc.Interfacedoi:10.1098/rsif.2009.0559PublishedonlineDevelopmentofmagnesiumcalciumphosphatebiocementforboneregenerationJunfengJia1,HuanjunZhou1,JieWei1,*,XinJiang1,HongHua1,FangpingChen1,ShichengWei2,Jung-WoogShin3andChang

2、shengLiu1,*1KeyLaboratoryforUltrafineMaterialsofMinistryofEducation,andEngineeringResearchCenterforBiomedicalMaterialsofMinistryofEducation,EastChinaUniversityofScienceandTechnology,Shanghai200237,People’sRepublicofChina2CenterforBiomedicalMaterialsandTissueEngineering,AcademyforAdvancedInter-di

3、sciplinaryStudies,PekingUniversity,Beijing100871,People’sRepublicofChina3DepartmentofBiomedicalEngineering,InjeUniversity,FirstResearchGroup/BK-21,Gimhae621-749,RepublicofKoreaMagnesiumcalciumphosphatebiocement(MCPB)withrapid-settingcharacteristicswasfabricatedbyusingthemixedpowdersofmagnesiumo

4、xide(MgO)andcalciumdihydrogenphosphate(Ca(H2PO4)2.H2O).TheresultsrevealedthattheMCPBhardenedaftermixingthepowderswithwaterforabout7min,andthecompressivestrengthreached43MPaaftersettingfor1h,indicatingthattheMCPBhadashortsettingtimeandhighinitialmechanicalstrength.Aftertheacid–basereactionofMCPB

5、containingMgOandCa(H2PO4)2.H2Oinamolarratioof2:1,thefinalhydratedproductswereMg3(PO4)2andCa3(PO4)2.TheMCPBwasdegradableinTris–HClsolutionandthedegradationratiowasobviouslyhigherthancalciumphosphatebiocement(CPB)becauseofitsfastdissol-ution.TheattachmentandproliferationoftheMG63cellsontheMCPBwere

6、significantlyenhancedincomparisonwithCPB,andthealkalinephosphataseactivityofMG63cellsontheMCPBwassignificantlyhigherthanontheCPBat7and14days.TheMG63cellswithnormalphenotypespreadwellontheMCPBsurfaces,andwereattachedincloseproxi-mitytothesubstrate,asseenbyscanningelectronmicroscopy(SEM).Theresults

7、demonstratedthattheMCPBhadagoodabilitytosupportcellattachment,proliferationanddifferentiation,andexhibitedgoodcytocompatibility.Keywords:magnesiumphosphate;calciumphosphate;biocement;degradation;biocompatibility1.INTRODUCTIONresor