THE EFFECT OF COBALT AND IRON SALTS ONTHE ANAEMIA OF PREMATURITY钴和铁盐的作用 早产儿贫血

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1、ArchDisChild:firstpublishedas10.1136/adc.29.144.85on1April1954.DownloadedfromTHEEFFECTOFCOBALTANDIRONSALTSONTHEANAEMIAOFPREMATURITYBYB.L.COLESandURSULAJAMESFromtheDepartmentofPaediatrics,ElizabethGarrettAndersonHospital(RoyalFreeHospitalGroup),London(RECEIVEDFORPU

2、BLICATIONNOVEMBER3,1953)Prematureinfantstendtoexhibithigherbloodprematurityisaself-limitingdiseasewithspon-valuesatbirththanfull-terminfants,butshowataneousrecoveryafteraboutthefourthmonth.InmorerapidandprolongedfallinbothhaemoglobintheseriesofAbtandNagel(1932),in

3、fantsofandredcellsandfrequentlydevelopanaemiawhichsevenmonths'gestationreachedvaluesof68%ismaximalataboutthethirdmonth(Parsonsandhaemoglobinand49millionredcellsat6months,Hawksley,1933).Lande(1919),usingaSahliandinfantsofeightmonths'gestation,69%haemo-method(standa

4、rd17'2g.equals100%)foundglobinand4*9millionredcellsat6months.averagelevelsof60to65%haemoglobinandMackay'scases(1935)hadrisento81-7%(birthaverageredcellsof3*3m./c.mm.atthethirdmonth.weight3-4lb.)and80-8%(birthweightapproxi-Inmanycasesthecountfellto50%.Shequotesmate

5、ly5lb.)at26weeksofage.ThesecaseswereallKnuckelwhogaveanaveragelevelof47%at3untreatedandformacontrasttothoseofMerrittmonthsthoughtheredcellswereproportionatelyandDavidson(1934),whoreportednosignificantlessreducedandaveraged4million.AbtandNagelchangesinthecountsfrom

6、thetimeofmaximum(1932)dividedtheircasesintothoseofsixtosevenanaemiatothetenthmonth.Iftheinitialfallhasmonths'gestationandthoseofeightmonths'beenverymarked,recoveryisdelayedandmaybegestation.Theformerreachedthelowestpointatincomplete.eightto12weekswithaveragelevels

7、of54%haemo-Thepathogenesisoftheanaemiaofprematurityglobinand3-3millionredcells.Thehaemoglobinisobscure.Lichtenstein(1921)foundanegativeironlevelofinfantsofeightmonths'gestationfelltobalanceinfourprematureinfantsnotreceivinghttp://adc.bmj.com/60%at8weeks,with4*0mil

8、lionredcellsadditionaliron,butthisworkwasnotconfirmed(169g.haemoglobinequals100%,Newcomer).bySnelling(1933).Josephs(1936)dividedtheInanotherseries(Merri