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1、MesotheliomaofChildhoodA.E.FRAIRE,MD,**t$S.COOPER,PHD,~S.D.GREENBERG,MD,'*t**P.BUFFLER,PHD,~ANDC.LANGSTON,MD**IIMalignantmesothelioma(MM)ofchildhoodisararebutimportantneoplasm.EightychildrenwithapreviousdiagnosisofMMwereidentified.Fourofthe80childrenhadexposuretoknownriskfa
2、ctors(twohadhistoryofexposuretoasbestos,onehadreceivedradiationtherapy,andonehadbeenexposedinuterotoisoniazid).Tissueslideswereavailableforindependentandjointreviewbyapanelofthreepathologistsin22ofthecases.TenwereacceptedasMM,ninewerereclassifiedasothermalignancies,andthree
3、wereconsideredtumorsofuncertainnature.SixofthetenchildrenwithMMwereboys,andfourweregirls.Eighthadpleuraltumors,andtwohadperitonealtumors.Fourdiedat7,8,18,and48monthsafterdiagnosis;threeremainedaliveat19,20,and59months;andthreehadnofollow-up.ThisreviewsuggeststhatMMofchildho
4、odisavalidentitywithagraveprognosis.Thetissuediagnosisisdifficultandisbestmadebyapanelofpathologists.TheavailableevidencedoesnotsupportacausalrelationshipbetweenMMandasbestos,radiation,orisoniazid.Cancer622338447,1988.UMEROUSREPORTSontheincidence,'-6pathogen-nomenclature,an
5、dindeedtheveryexistenceofchild-Nesi~,~-IOepidemiology,''-I6asbestosrelation-hoodmesothelioma.hip,'^-^'path~logy,~'-~~hi~tochemistry,~~-~~electronWeevaluatedclinicaldataandtissueslidesfrompub-micro~copy,~~*~'ands~rvival~~~~~ofadultlishedandunpublishedcasesofchildhoodmesothel
6、i-mesotheliomahavebeenpublishedoverthelast30omaintheUnitedStatesandabroadinanattempttoyears.Incontrast,thereislittleinformationconcern-clarifythenatureofthisdiseaseinchildren.Apanelofingmesotheliomaofchildhood.Withfewexcep-threepathologistsindependentlyreviewedallavailablet
7、ion~~~-~~thisinformationislimitedtoindividualcasetissueslidestoconfirmthehistopathologicdiagnosis.Inreport^.'^-^^Moreover,adiscussionofmesotheliomaofaddition,theassociationofchildhoodmesotheliomachildhoodinmostcontemporarytextbooksofgeneralwithknownriskfactors,suchasexposur
8、etoasbestos,"pathology,6'pediatricpath~logy,~~,~~andclinicalpediat-andisoniazid68w
