A Data Mining Approach for Optimization of Acute Inflammation Therapy一种用于急性炎症治疗优化的数据挖掘方法

《A Data Mining Approach for Optimization of Acute Inflammation Therapy一种用于急性炎症治疗优化的数据挖掘方法》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、ADataMiningApproachforOptimizationofAcuteInflammationTherapyVladanRadosavljevicKostaRistovskiZoranObradovicTempleUniversityTempleUniversityTempleUniversityPhiladelphia,USAPhiladelphia,USAPhiladelphia,USAvladan@temple.edukosta@temple.eduzoran.obradovic@temple.eduAb

2、stract—Acuteinflammationisamedicalconditionwhichtoolsthatcanaidcliniciansindesigningoptimalstrategiesoccursoverseconds,minutesorhoursandischaracterizedforinflammationtreatments.asasystemicinflammatoryresponsetoaninfection.Delayingtreatmentbyonlyonehourdecreasespatient

3、chanceofsurvivalOneofthetoolsthatcanbeusedforfindingoptimalbyabout7%.Therefore,thereisacriticalneedfortoolsthattherapyismodelpredictivecontrol(MPC).MPCalgorithmscanaidtherapyoptimizationforthispotentiallyfatalcondition.aresuitableformedicalapplications[3],[5],[8],[9

4、]pri-Towardsthisobjectivewedevelopedadatadrivenapproachmarilybecauseoftheirabilitytodealwithalargenumberfortherapyoptimizationwhereapredictivemodelforpatients’ofvariablesandconstraintsthatarenotwelladdressedbehaviorislearneddirectlyfromhistoricaldata.Assuch,thepred

5、ictivemodelisincorporatedintoamodelpredictivewithotherapproaches.ThekeycomponentofMPCisacontroloptimizationalgorithmtofindoptimaltherapy,whichpredictivemodel,whichisusedtopredictapatient’sfuturewillleadthepatienttoahealthystate.Tosaveonthecoststatesasaresponsetothet

6、reatment.MPCusespredictionsofclinicaltrialsandpotentialfailure,weevaluatedourmodeloffuturestatesandasetofconstraintstocalculateanonapopulationofvirtualpatientscapableofemulatingtheoptimalsetoffuturetreatmentsthatwillguidethepatientinflammatoryresponse.Patientsaretre

7、atedwithtwodrugsforwhichdosageandtimingarecriticalfortheoutcometoahealthystate.ThequalityofMPCdirectlydependsonofthetreatment.Ourresultsshowsignificantimprovementtheabilityofthepredictivemodeltoaccuratelypredicttheinpercentageofhealthyoutcomescomparingtopreviouslyfu

8、turestates.Deterministicpredictivemodelsthatrelyonproposedmethodsforacuteinflammationtreatmentfoundindomainknowledgeassumptionsoftenfailwhendealin