资源描述：
《Abe-2007-NMDA-receptor activa》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、NeuronArticleNMDA-ReceptorActivationInducesCalpain-Mediatedb-CateninCleavagesforTriggeringGeneExpression11,*KentaroAbeandMasatoshiTakeichi1GraduateSchoolofBiostudies,KyotoUniversity,Kitashirakawa,Sakyo-ku,Kyoto606-8502,andRIKENCenterforDevelopmentalBiol
2、ogy,2-2-3Minatojima-Minamimachi,Chuo-ku,Kobe650-0047,Japan*Correspondence:takeichi@cdb.riken.jpDOI10.1016/j.neuron.2007.01.016SUMMARYetal.,1997;Liuetal.,2002;Rubinfeldetal.,1996).OnceWntsignalsareactivated,ontheotherhand,theseproteo-ThecanonicalWnt-b-ca
3、teninsignalingpathwaylyticprocessesaresuppressedduetotheinhibitionofisimportantforavarietyofdevelopmentalphe-GSK-3bactivity.Then,thestabilizedb-cateninistranslo-nomenaaswellasforcarcinogenesis.Here,wecatedintothenuclei,whereitassociateswiththetran-showt
4、hat,inhippocampalneurons,NMDA-scriptionfactorTcf/Lefandtherebyactivatesgenetran-receptor-dependentactivationofcalpainin-scription.Theb-catenin-Tcfsystemisessentialforawidevarietyofdevelopmentalphenomena(LoganandNusse,ducedthecleavageofb-cateninattheNter
5、mi-2004)andisinvolvedincarcinogenesis(Polakis,2000),nus,generatingstable,truncatedforms.Thesebutitsphysiologicalroleinmatureneuronsisnotwellun-b-cateninfragmentsaccumulatedinthenucleusderstood.Nevertheless,malactivationofb-catenin-Tcf-andinducedTcf/Lef-
6、dependentgenetranscrip-mediatedgeneregulationhasbeenreportedforvarioustion.WeidentifiedFosl1,oneoftheimmediate-neurologicaldiseases,includingAlzheimer’sdiseaseearlygenes,asatargetofthissignalingpath-(Chongetal.,2005;DeFerrariandInestrosa,2000)andbi-way.I
7、naddition,exploratorybehaviorbymicepolardisorder(GouldandManji,2002),implyingthatTcf/resultedinasimilarcleavageofb-catenin,asLef-mediatedgenetranscriptionplaysaroleinbrainfunc-wellasactivationoftheTcfsignalingpathway,tions.TheWntsignalingsystemhasaltern
8、ativepathways,inhippocampalneurons.Bothb-catenincleav-collectivelycalledthenoncanonicalpathway(Montcou-ageandTcf-dependentgenetranscriptionwerequioletal.,2006),thatarealsoimportantforvariousbiolog-icalphenomena,suchascellpolarity
