2015-microRNA regulation of Wnt signaling pathways in development

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1、CellularSignalling27(2015)1380–1391ContentslistsavailableatScienceDirectCellularSignallingjournalhomepage:www.elsevier.com/locate/cellsigReviewmicroRNAregulationofWntsignalingpathwaysindevelopmentanddiseaseJiaL.Song⁎,PriyaNigam,SenelS.Tektas,EricaSelvaDepartmentofBiologicalSciences,Univ

2、ersityofDelaware,Newark,DE19716,USAarticleinfoabstractArticlehistory:WntsignalingpathwaysandmicroRNAs(miRNAs)arecriticalregulatorsofdevelopment.AberrantWntsignal-Received2March2015ingpathwaysandmiRNAlevelsleadtodevelopmentaldefectsanddiversehumanpathologiesincludingbutnotReceivedinrevis

3、edform24March2015limitedtocancer.Wntsignalingpathwaysregulateaplethoraofcellularprocessesduringembryonicdevelop-Accepted24March2015mentandmaintainhomeostasisofadulttissues.AmajorityofWntsignalingcomponentsareregulatedbyAvailableonline2April2015miRNAswhicharesmallnoncodingRNAsthatareexpr

4、essedinbothanimalsandplants.Inanimalcells,miRNAsfinetunegeneexpressionbypairingprimarilytothe3′untranslatedregionofproteincodingmRNAstorepressKeywords:Post-transcriptionalregulationtargetmRNAtranslationand/orinducetargetdegradation.miRNA-mediatedregulationofsignalingtransductionRegulator

5、ynetworkpathwaysisimportantinmodulatingdose-sensitiveresponseofcellstosignalingmolecules.Thisreviewdis-β-catenincussescomponentsoftheWntsignalingpathwaysthatareregulatedbymiRNAsinthecontextofdevelopmentNon-canonicalWntsignalinganddiseases.AfundamentalunderstandingofmiRNAfunctionsinWntsi

6、gnalingtransductionpathwaysmayCanceryieldnewinsightintocrosstalksofregulatorymechanismsessentialfordevelopmentanddiseasepathophysiol-ogyleadingtonoveltherapeutics.©2015ElsevierInc.Allrightsreserved.Contents1.Introduction.............................................................13812.

7、Wntsignalingpathwaysindevelopment................................................13812.1.Thecanonicalβ-catenin-dependentWntpathway........................................13812.2.Thenon-canonicalWntpathways................................................13822.3.ProcessingofWntli