Dynapenic-abdominal-obesity-as-predictor-of-mortality-and-disability-worsening-in-older-adults-A-10-year-prospective-study_2016_Clinical-Nutrition

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1、ClinicalNutrition35(2016)199e204ContentslistsavailableatScienceDirectClinicalNutritionjournalhomepage:http://www.elsevier.com/locate/clnuOriginalarticleDynapenicabdominalobesityaspredictorofmortalityanddisabilityworseninginolderadults:A10-yearprospectivestudya,*aaaaAndreaP.R

2、ossi,FrancescoFantin,CesareCaliari,ElenaZoico,GloriaMazzali,aaabMarinaZanardo,PaoloBertassello,ValeriaZanandrea,RoccoMicciolo,aMauroZamboniaDepartmentofMedicine,GeriatricsDivision,UniversityofVerona,Verona,ItalybDepartmentofStatistics,UniversityofTrento,Trento,Italyarticlein

3、fosummaryArticlehistory:TherearerelativelyfewprospectivestudiesevaluatingthecombinedeffectofabdominalobesityandlowReceived4January2015musclestrengthonworseningdisabilityandonmortality.ThestudyaimedatevaluatingprospectivelyAccepted12February2015theprognosticvalueofdynapenicab

4、dominalobesitydefinitionondisabilityworseningina5.5-yearfollow-upandmortalityina10-yearfollow-up.Keywords:Methods:In93menand169womenagedbetween66and78years,legisometricstrength,waistSarcopenicobesitycircumference(WC),BMI,glycemia,HOMA,lipidprofile,vitaminD3,albumin,fibrinogen,p

5、hysicalac-Musclestrengthtivitylevel,income,smokingstatusandcomorbiditieswereevaluatedatthebaseline.DynapeniaReporteddisabilitiesweremeasuredatbaseline,1-y,2-y,3-yand5.5-yfollow-upandmortalityratewasDisabilityMortalityevaluatedduringa10-yfollow-up.Thestudypopulationwascategor

6、izedindynapenicabdominalobese(D/AO),nondynapenicabdominalobese(ND/AO),dynapenicnonabdominalobese(D/NAO),non-dynapenicnonabdominalobese(ND/NAO)accordingtomusclestrength/WCtertiles.Results:D/NAOsubjectspresentedadisabilityworseningriskof1.69times(95%CI:1.11e2.57),ND/AOsubjects

7、showeda2-foldincreaseinrisk(95%CI:1.34e2.98),whilebeingD/AOmorethantrebledtherisk,evenafterconsideringconfoundingvariables(HR:3.39,95%CI:1.91e6.02).Mortalityriskafteradjustmentforotherconfoundingvariableswas1.57(95%CI:1.16e2.13)forND/AOand2.46(95%CI:1.34e4.52)forD/AO.Conclus

8、ions:Dynapenicabdominalobesesubjectsareathigherriskofworseningdisabilityand