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1、Psychopharmacology(2015)232:17–37DOI10.1007/s00213-014-3636-9ORIGINALINVESTIGATIONCognitiveimpactofcytotoxicagentsinmiceR.Seigers&M.Loos&O.VanTellingen&W.Boogerd&A.B.Smit&S.B.SchagenReceived:19December2013/Accepted:5May2014/Publishedonline:4June2014#Springer-VerlagBerlinHeide
2、lberg2014Abstractmeasuresofbehaviorandcognitivetaskperformance:RationaleandobjectivesAdjuvantchemotherapyisassociat-spontaneousbehaviorinanautomatedhomecage,openedwithchangesincognitioninasubgroupofcancerpatients.field,novellocationrecognition(NLR),novelobjectrec-Chemotherapy
3、isgenerallygivenasacombinationofcyto-ognition(NOR),Barnesmaze,contextualfearcondition-toxicagents,whichmakesithardtodefinetheagentrespon-ing,andasimplechoicereactiontimetask(SCRTT).siblefortheseobservedchanges.Literatureonanimalexper-ResultsCyclophosphamide,docetaxel,anddoxor
4、ubicinad-imentshasbeendifficulttointerpretduetovarianceinexper-ministrationaffectedspontaneousactivityintheautomatedimentalsetup.homecage.Allcytotoxicagentsaffectedmemory(NLRand/MethodsWeexaminedtheeffectsofcytotoxicagentsorNOR).SpatialmemorymeasuredintheBarnesmazewasadminist
5、eredseparatelyonvariouscognitivemeasuresinaffectedafteradministrationwithdoxorubicin,5-fluorouracil,astandardizedanimalmodel.MaleC57Bl/6micere-andtopotecan.DecreasedinhibitionintheSCRTTwasob-ceivedcyclophosphamide,docetaxel,doxorubicin,5-servedaftertreatmentwithcyclophosphami
6、de,docetaxel,andfluorouracil,methotrexate,ortopotecan.Theseagentstopotecan.representdifferentcompoundclassesbasedontheirwork-ConclusionsOurdatashowthat,inmice,asingletreat-ingmechanismandarefrequentlyprescribedintheclinic.mentwithacytotoxicagentcausescognitiveimpairment.Acont
7、rolgroupreceivedsaline.BehavioraltestingstartedNotallcytotoxicagentsaffectedthesamecognitivedo-2or15weeksaftertreatmentandincludedtestinggeneralmains,whichmightbeexplainedbydifferencesinwork-ingmechanismsofthevariousagents.TheauthorsA.B.SmitandS.B.Schagenhaveequalcontribution
8、.KeywordsMice.Chemotherapy.Cytotoxicagent.R.Seigers:S.B.Schagen(*)Be
