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1、Hemolysiseffectandcalcium-phosphateprecipitationofheat-organic-filmtreatedmagnesiumGAOJia-cheng(高家诚),QIAOLi-ying(乔丽英),LILong-chuan(李龙川),WANGYong(王勇)CollegeofMaterialsScienceandEngineering,ChongqingUniversity,Chongqing400030,ChinaReceived8August2005;accepted22December2005Abstract:
2、Aheat-organic-filmsprocesswasemployedtoinducecalcium-phosphateapatitesformationonmagnesium,consequentlythecorrosionresistanceandhemolysispropertiesofmagnesiumwereimprovedforbiomedicalapplications.Firstly,magnesiumsampleswereheat-treatedat773Kfor10h;secondly,stearicacidfilmswereco
3、atedonthesurfaceoftheheat-treatedmagnesium.Thenthesurfacemodifiedmagnesiumwassoakedinsimulatedbodyfluid(SBF)totestitscorrosionresistance.Theresultsshowthattheheattreatmentprocessallowsmagnesiumtoformadenseoxidelayerwithathicknessofaround20µm,therebythesurfacemodifiedmagnesiumhash
4、ighercorrosionresistance.After24hinSBFislandapatitewasdepositedonmagnesium.TheunevenlyprecipitateswerecharacterizedbyXRDandFTIRasthemixtureofhydroxyapatite(HA)andoctacalciumphosphate(OCP).Thepreliminaryhemolysisexperimentindicatesthatuntreatedmagnesiumhashemolyticeffect(about60%)
5、;whereastheheat-organicfilmtreatedsampleshasnohemolyticeffect.Themechanismoffastnucleationandgrowthofcalcium-phosphateapatitesonsurfacemodifiedmagnesiuminSBFwasalsodiscussed.Keywords:magnesium;biomaterials;heat-organicfilms;corrosionresistance;hemolysisRecently,thereisanattractiv
6、estrategytodeposit1Introductioninorganicphasesonthemetalwithsurfactantmonolayers.ThisbiomimeticapproachisacomplexprocessthatVariouskindsofmetal-basedbiomaterialshaveinvolvesthecontrollednucleationandgrowthofbeenwidelyusedinclinic.Howevertheapplicationofinorganicphasesthroughthefu
7、nctionalsitesonthefilms.NiTiand316LislimitedbythepotentialhealthhazardStudiesofbiomimeticsynthesizingcalcium-phosphateowingtothereleaseofNiandCrions[1].Titaniumcoatingsontitaniumimplantshavebeenreported[4,5].alloy,whichhasextensivelyservedassubstituteforStudiesofbiomineralization
8、onmagnesium,however,humanhardtissues,was