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1、>TMTTManuscriptIMS2009[1491]<1IntegratedBroadbandMicrowaveandMicrofluidicSensordedicatedtoBioengineeringKatiaGrenier,Member,IEEE,DavidDubuc,Paul-EmilePoleni,MomokoKumemura,HiroshiToshiyoshi,Member,IEEE,TeruoFujii,Member,IEEE,andHiroyukiFujita,Member,IEEEOntheo
2、therhand,theuseofelectromagneticwavestoAbstract—ThispaperpresentsaninnovativeRadioFrequencycharacterizeandstudythedielectricpropertiesofbiological(RF)basedbiosensor,whichalliesbothRF/microwavedetectionsubstancessuchastissuesandcellssuspensionslikebloodandamicr
3、ofluidicnetworkfortimeefficientandaccuratewaswellestablishedbySchwanandStuchlynotably[2]-[5].biologicalanalysis.ItiscomposedofacoplanarwaveguidewithaTechnologiesusedatthistimewerehoweverquitemicrofluidicchannelplacedontop.Thankstoanappropriatede-embeddingtechn
4、iqueandmodelingofthemeasurements,thecumbersome.Microtechnologies,whicharenowavailable,relativeeffectivepermittivityofHUVEChumancellshasbeenopenthedoortotheelaborationofnewandmoreappropriateevaluatedsuccessfully.Furthermore,thesensorhasbeentoolsbasedona“lab-on-
5、a-chip”approachforbiologicalexperimentedforvariouscellsconcentrationsinsuspension,analysisandelaboratedmanipulations.whichvalidatesitsuseforbioengineeringandespeciallycellsSincefewyears,theideaofdevelopingbiosensorsbasedonquantificationandcountinginsolution,wi
6、thoutanydirectRFdetectionandmicrotechnologiesforbiologicalcontactoruseoflabelsonthecells,inthecontrarytootherusualbiosensorstypes(optical,mechanicalorDC/lowfrequencycharacterizationisconsequentlyemerging,butstilldetectionbasedones).sporadically[6]-[7].Allyingb
7、othRFandmicro-fabricationspresentsindeedthecolossaladvantagesof(1)beinganonIndexTerms—Coplanarwaveguides,permittivity,biomedicalinvasiveandcontactlesssolution,withoutanyrequirementoftransducers,microwavespectroscopy,biology,fluidics.markersorothermodifications
8、,i.e.nondestructive;(2)allowingparticularlyquickmeasurementsandpreciseI.INTRODUCTIONcharacterizations,aswellasrealtimemonitoringonalargetimescale;(3)intotalrespectandcompatibilityw
