资源描述：
《Surface_modification_of_polymer-based_microfluidic_devices_》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、AnalyticaChimicaActa470(2002)8799Surfacemodificationofpolymer-basedmicrofluidicdevicesStevenA.Soper∗,AlyssaC.Henry,BikasVaidya,MichelleGalloway,MusundiWabuyele,RobinL.McCarley1ChoppinLaboratoriesofChemistry,DepartmentofChemistry,LouisianaStateUniversity,232ChoppinHall,Bat
2、onRouge,LA70803-1804,USAReceived16November2001;receivedinrevisedform11April2002;accepted22April2002AbstractWereportthechemicalmodificationofpoly(methylmethacrylate)(PMMA),andpoly(carbonate)(PC)surfacesforapplicationsinmicrofluidicsystems.ForPMMA,areactionofthesurfacemethy
3、lestergroupswithamonoanionof,-diaminoalkanes(aminolysisreaction)toyieldamine-terminatedPMMAsurfaceswillbedescribed.Furthermore,itwasfoundthattheaminefunctionalitiesweretetheredtothePMMAbackbonethroughanalkanebridgetoamidebondsformedduringtheaminolysisofthesurfaceester
4、functionalities.Theelectro-osmoticflow(EOF)inaminated-PMMAmicrochannelswasreversedwhencomparedtothatinunmodifiedchannels.Finally,theavailabilityofthesurfaceaminegroupswasfurtherdemonstratedbytheirreactionwithn-octadecane1-isocyanatetoformPMMAsurfacesterminatedwithwellorde
5、redandhighlycrystallineoctadecanechains,appropriateforperformingreverse-phaseseparations.Examplesofreverse-phasesepa-rationsofion-paireddouble-strandedDNAsinelectricfields(capillaryelectrochromatography(CEC))willbedemonstratedusingaPMMA-basedfluidicchip.ForPC,sulfonationo
6、fthesurfacewithSO3willbedescribed;thissulfonationmakesthesurfaceveryhydrophilic.EOFstudiesofthesulfonated-PCsurfacesindicatedchangesinthepH-dependentprofilewhencomparedtounmodifiedPC.©2002ElsevierScienceB.V.Allrightsreserved.Keywords:Surfacemodification;Polymermicrodevices
7、;MEMS;DNAelectrophoresis1.IntroductionInrecentyears,analyticalMEMShavebeenfabri-catedinglassbymeansofwetchemicaletching[25].Microelectromechanicalsystems(MEMS),haveDuetotheisotropicnatureoftheetchingprocessinrecentlyenteredtheforefrontofinstrumentationde-glass,veryshall
8、owchannelswithlowaspectratiosvelopmentinanalyticalchemistry.MEMSoffertheresult.Thiscanbeovercomeusingdeepreact
