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1、LecturesonSTATISTICALPHYSICSANDPROTEINFOLDINGThispageintentionallyleftblankLecturesonSTATISTICALPHYSICSANDPROTEINFOLDINGKersonHuangMassachusettsInstituteofTechnologyWeWorldScientificNEWJERSEY·LONDON·SINGAPORE·BEIJING·SHANGHAI·HONGKONG·TAIPEI·CHENNAIPublishedbyWorld
2、ScientificPublishingCo.Pte.Ltd.5TohTuckLink,Singapore596224USAoffice:27WarrenStreet,Suite401-402,Hackensack,NJ07601UKoffice:57SheltonStreet,CoventGarden,LondonWC2H9HEBritishLibraryCataloguing-in-PublicationDataAcataloguerecordforthisbookisavailablefromtheBritishLib
3、rary.Firstpublished2005Reprinted2006LECTURESONSTATISTICALPHYSICSANDPROTEINFOLDINGCopyright©2005byWorldScientificPublishingCo.Pte.Ltd.Allrightsreserved.Thisbook,orpartsthereof,maynotbereproducedinanyformorbyanymeans,electronicormechanical,includingphotocopying,recor
4、dingoranyinformationstorageandretrievalsystemnowknownortobeinvented,withoutwrittenpermissionfromthePublisher.Forphotocopyingofmaterialinthisvolume,pleasepayacopyingfeethroughtheCopyrightClearanceCenter,Inc.,222RosewoodDrive,Danvers,MA01923,USA.Inthiscasepermissiont
5、ophotocopyisnotrequiredfromthepublisher.ISBN981-256-143-9ISBN981-256-150-1(pbk)TypesetbyStallionPressEmail:enquiries@stallionpress.comPrintedinSingapore.June4,200513:51WSPC/BookTrimSizefor9inx6inspi-b264ForewordThisbookcomprisesaseriesoflecturesgivenbytheauthoratth
6、eZhouPei-YuanCenterforAppliedMathematicsatTsinghuaUniversitytointroduceresearchinbiology—specifically,proteinstructure—toindividualswithabackgroundinothersciencesthatalsoincludesaknowledgeinstatisticalphysics.Thisisatimelypub-lication,sincethecurrentperceptionisthat
7、biologyandbiophysicswillundergorapiddevelopmentthroughapplicationsoftheprinciplesofstatisticalphysics,includingstatisticalmechanics,kinetictheory,andstochasticprocesses.Thechaptersbeginwithagoodthoroughintroductiontostatis-ticalphysics(Chapters1–10).Thepresentation
8、issomewhattiltedtowardsbiologicalapplicationsinthesecondpartofthebook(Chapters11–16).Specificbiophysicaltopicsarethenpresentedinthisstylewhiletheg