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1、naturepublishinggrouporiginalcontributionsPolymorphismsofACE2areAssociatedwithBloodPressureResponsetoColdPressorTest:TheGenSaltStudyJianfengHuang1,ShufengChen1,XiangfengLu1,QiZhao2,DabeeruC.Rao3,CashellE.Jaquish4,JamesE.Hixson5,JichunChen1,LaiyuanWang1,JieC
2、ao1,JianxinLi1,HongfanLi1,JiangHe2,6,De-PeiLiu7andDongfengGu1,8BackgroundresultsIncreasedbloodpressure(BP)reactivitytocoldpressortest(CPt)Inwomen,threesNPs(rs1514283,rs4646176,andrs879922)oftheisariskfactorforhypertension.geneticfactorsmayinfluencetheACE2ge
3、neweresignificantlyassociatedwiththediastolicBP(DBP)variationofBPresponsetoCPtamongindividuals.WeexploredtheresponsetoCPtinthegeneralandrecessivegeneticmodelsafterassociationofgeneticvariantsintheapelinsystemgenes(APLN,adjustmentformultipletesting(allfalsed
4、iscoveryrateq<0.05).APLNRandACE2)andBPresponsetoCPtinaChinesepopulation.therewerenosignificantassociationsofpolymorphismsinAPLNandAPLNRgeneswithBPresponsestoCPt.Methodsatotalof1,998HanChineseparticipantsfromthegeneticconclusIonsEpidemiologyNetworkofsaltsens
5、itivitycompletedaCPt.theOurstudyidentifiedgeneticvariantsintheACE2genethatwerepercentagechangesofBPrightaftertheendofice-waterimmersionsignificantlyassociatedwithDBPresponsestocoldstressinthewereusedasthemeasurementofBPresponsestoCPt.twenty-Chinesefemalepop
6、ulation.Futurestudiesarewarrantedtoconfirmtwosinglenucleotidepolymorphisms(sNPs)wereselectedandthesefindings.genotyped,includingbothtagandpotentialfunctionalsNPsoftheKeywords:angiotensinconvertingenzyme2;apelin;apelinreceptor;APLN,APLNR,andACE2genes.amixed-
7、effectlinearmodelwasusedbloodpressure;coldpressortest;hypertensiontoassesstheassociationbetweensNPsandBPresponsestoCPt.AmericanJournalofHypertension,advanceonlinepublication31May2012;doi:10.1038/ajh.2012.61IntroductIonhypertensioninnormotensivepersons.1–4Tw
8、inandpedigreeThecoldpressortest(CPT),whichmeasurestheresponseofstudiesreportedthatBPreactivitytoCPTwassignificantlybloodpressure(BP)tothestimulusofexternalcold,haslonginfluencedbygeneticfactors.5–10The
