A Brief History of GreatDiscoveries in Pharma

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1、0031-6997/07/5904-289–359$20.00PHARMACOLOGICALREVIEWSVol.59,No.4Copyright©2007byTheAmericanSocietyforPharmacologyandExperimentalTherapeutics70102/3301314PharmacolRev59:289–359,2007PrintedinU.S.AABriefHistoryofGreatDiscoveriesinPharmacology:InCelebrationoftheCenten

2、nialAnniversaryoftheFoundingoftheAmericanSocietyofPharmacologyandExperimentalTherapeuticsRONALDP.RUBINTheStateUniversityofNewYorkatBuffalo,SchoolofMedicineandBiomedicalSciences,Buffalo,NewYorkForeword................................................................

3、..............290I.Prologue...............................................................................290II.Majordiscoveriesinpharmacology.......................................................291A.ThomasRentonElliott:elaborationoftheconceptofchemicalneurotran

4、smission..........291B.SirHenryDaleandOttoLoewi:chemicaltransmissionofnerveimpulses.................2941.SirHenryDale...................................................................2942.OttoLoewi..................................................................

5、.....295C.DanielBovet:syntheticcompoundsthatinhibittheactionofcertainbodysubstances,andespeciallytheiractiononthevascularsystemandskeletalmuscle.......................298D.UlfvonEuler,JuliusAxelrod,andSirBernardKatz:humoraltransmittersinthenerveterminalsandthemech

6、anismfortheirstorage,release,andinactivation.................3011.UlfvonEuler....................................................................3012.JuliusAxelrod....................................................................3013.SirBernardKatz..............

7、...................................................305E.ArvidCarlsson:signaltransductioninthenervoussystem..............................306F.SirJamesBlack,GertrudeElion,andGeorgeHitchings:importantprinciplesfordrugtreatment.........................................

8、..................................3081.SirJamesBlack..................................................................3082.GertrudeElionandGeorgeHitchin