The CP Molecule Labyrinth_A Paradigm of How Endeavors in Total Synthesis Lead to Discoveries and Inventions in Organic Synthesis

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1、REVIEWSTheCPMoleculeLabyrinth:AParadigmofHowEndeavorsinTotalSynthesisLeadtoDiscoveriesandInventionsinOrganicSynthesisK.C.Nicolaou*andPhilS.BaranDedicatedtoMrs.NikiGoulandrisforheroutstandingcontributionstohumanityandPlanetEarthontheoccasionoftheopeningoftheGAIACenterforEnvironmentalResearchandE

2、ducationattheGoulandrisNaturalHistoryMuseuminAthens,Greece.ImagineanartistcarvingasculptureHerculeannatureofthetaskandtheedMinotaur,whichheaccomplishedfromamarbleslabandfindinggoldrewardsthataccompanyit,onemustthroughbrilliance,skill,andbraverynuggetsintheprocess.Thisthoughtissensethedetailsoft

3、heenterprisehavingtraversedthefamouslabyrinthnotafar-fetcheddescriptionofthebehindthescenes.Amorevividde-withthehelpofAriadne.ThisstoryworkofasyntheticchemistpursuingscriptionoftotalsynthesisasastrugglefromGreekmythologycomesaliveinthetotalsynthesisofanaturalproduct.againstatoughopponentisperha

4、psmodernsyntheticexpeditionstowardAttheendoftheday,heorshewillbeappropriatetodramatizetheseele-naturalproductsasexemplifiedbythejudgedbytheartistryofthefinalworkmentsoftheexperience.InthisarticletotalsynthesisoftheCPmoleculesandtheweightofthegolddiscoveredwedescribeonesuchendeavoroftotalwhichse

5、rveasaparadigmformodernintheprocess.However,ascolorfulassynthesiswhich,inadditiontoreachingtotalsynthesisendeavors,wherethethisdescriptionoftotalsynthesismaythetargetmolecule,resultedinaobjectivesarediscoveryandinventionbe,itdoesnotentirelycapturethewealthofnewsyntheticstrategiesandinthebroader

6、senseoforganicsyn-essenceoftheendeavor,forthereistechnologiesforchemicalsynthesis.thesis.muchmoretobetold,especiallywithThetotalsynthesisoftheCPmoleculesregardtothecontrastoffrustratingiscomparedtoTheseus×mostcelebrat-Keywords:CPmolecules¥naturalfailuresandexhilaratingmomentsofedathlos(Greekfor

7、exploit,accom-products¥syntheticmethods¥totaldiscovery.Tofullyappreciatetheoftenplishment):theconquestofthedread-synthesis1.Prologueweresentintothemaze-likelabyrinthtofacethedeadlyMinotaurwhowashalfman,halfbull.™Athenshadbeenatwar