USEPA alternatives_assessment_criteria_for_hazard_eval

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1、DesignfortheEnvironmentProgramAlternativesAssessmentCriteriaforHazardEvaluationVersion2.0August2011OfficeofPollutionPrevention&ToxicsU.S.EnvironmentalProtectionAgencyU.S.EPADesignfortheEnvironmentProgramVersion2.0AlternativesAssessmentCriteriaforHazardEvaluationAugust2011ToensurethattheAlt

2、ernativesAssessmentCriteriaforHazardEvaluationremainrelevantandusefulfordistinguishingamongchemicals,DfEmayupdatethecriteriabasedonexperienceconductingalternativesassessmentsandonstakeholderinput.Additionaldevelopmentslikelytopromptcriteriareview,reevaluation,andpossiblerevisionincludechan

3、gestotheGloballyHarmonizedSystem(GHS)orEPAprogrammaticcriteria,whichareintegraltotheAlternativesAssessmentCriteria,aswellasadvancesinscience,suchasthoserelatingtoendpointcharacterizationortestingmethodologies.-1-U.S.EPADesignfortheEnvironmentProgramVersion2.0AlternativesAssessmentCriteriaf

4、orHazardEvaluationAugust2011TableofContents1.Introduction........................................................................................................................-4-2.GeneralRequirements.........................................................................................

5、...............-5-3.Terms...................................................................................................................................-6-4.ToxicologicalCriteria.........................................................................................................-10

6、-4.1.HumanHealthEffects................................................................................................-11-4.1.1AcuteMammalianToxicity...............................................................................-11-4.1.2Carcinogenicity.....................................

7、.............................................................-12-4.1.3Mutagenicity/Genotoxicity...............................................................................-13-4.1.4ReproductiveandDevelopmentalToxicity(includingDevelopmentalNeurotoxicity)....