Comparison of Neurocognitive Function After Anthracycline-Based Chemotherapy vs Nonanthracycline-Based Chemotherapy

Comparison of Neurocognitive Function After Anthracycline-Based Chemotherapy vs Nonanthracycline-Based Chemotherapy

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时间:2019-07-11

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1、LettersRESEARCHLETTERanthracycline,orchemotherapywithanthracycline.Theneuro-psychologicaltestsselectedfortheseanalysesmeasurememory,ComparisonofNeurocognitiveFunctionprocessingspeed,andexecutivefunctions.ThefullstudydesignAfterAnthracycline-BasedChemotherapyandtheneuropsychologicalbatteryhavebeen

2、detailedvsNonanthracycline-BasedChemotherapy2elsewhere.RawneuropsychologicaltestscoreswerecomparedAsawhole,thepossibleadverseeffectsofbreastcancerandamongtreatmentgroupsacrossall4assessmentpointsusingitstreatmentoncognitivefunctionarenowwidelyacknowl-mixedmodelscontrollingforage,intelligencequoti

3、ent,andhis-edged,buttherisksofspecificchemotherapiesarestillunde-toryoftreatmentwithendocrinetherapy.TheMBSwasapprovedtermined.Arecentretrospectivecross-sectionalstudyfoundbytheUniversityofCaliforniaLosAngelesinstitutionalreviewlowermemoryscoresonaverage2yearsaftertreatmentamongboard,andallpartic

4、ipantsprovidedwritteninformedconsent.breastcancersurvivorswhounderwentanthracyclinetreat-mentvsthosewhounderwentotherchemotherapiesornoche-Results

5、SeetheTableforgroupdemographicandclinicalchar-motherapy,accompaniedbylowerfunctionalconnectivityinacteristicsatbaseline(within3monthsfollowingprimaryt

6、reat-1defaultmodenetworkregions.However,inanearlierreportment).Ofthe7neuropsychologicaltestsexaminedinmixedexaminingalargesampleofpatientswithbreastcancerim-models,therewerenosignificantgroupeffects.Thereweremediatelyafterprimarytreatmentandadjuvantchemo-alsonosignificantgroup×timeinteractionsina

7、nyofthe72therapy(theMindBodyStudy[MBS]),wefoundnoassocia-mixedmodels(P>.05).Inadditiontothe4neuropsychologi-tionbetweenanthracyclineexposureandcognitivecomplaints.caltestresultspresentedintheFigure,nogroupeffectsorin-Todetermineriskoflastingcognitivedeclinewithanthracy-teractionswerefoundontestso

8、fexecutivefunctioning/clinetreatment,weperformedasecondaryanalysisofcogni-verbalfluency(FAS)orvisualmemory(BriefVisualMemorytivefunctionacrossmultipledomainsfromtheMBSprospec-Test–Revised,totalanddelayedrecallscores).t

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