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1、ExpertReviewofProteomicsISSN:1478-9450(Print)1744-8387(Online)Journalhomepage:http://www.tandfonline.com/loi/ieru20TheroleofmassspectrometryinthecharacterizationofbiologicproteinproductsDeepaliRathore,AnnelieseFaustino,JohnSchiel,EricPang,MichaelBoyne&SarahRogstadTocitethisarticl
2、e:DeepaliRathore,AnnelieseFaustino,JohnSchiel,EricPang,MichaelBoyne&SarahRogstad(2018)Theroleofmassspectrometryinthecharacterizationofbiologicproteinproducts,ExpertReviewofProteomics,15:5,431-449,DOI:10.1080/14789450.2018.1469982Tolinktothisarticle:https://doi.org/10.1080/1478945
3、0.2018.1469982Acceptedauthorversionpostedonline:25Apr2018.Publishedonline:10May2018.SubmityourarticletothisjournalArticleviews:226ViewCrossmarkdataCitingarticles:1ViewcitingarticlesFullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?
4、journalCode=ieru20EXPERTREVIEWOFPROTEOMICS2018,VOL.15,NO.5,431–449https://doi.org/10.1080/14789450.2018.1469982REVIEWTheroleofmassspectrometryinthecharacterizationofbiologicproteinproductsDeepaliRathorea,b,AnnelieseFaustino*a,JohnSchielc,EricPangd,MichaelBoynea,eandSarahRogstadaa
5、DivisionofPharmaceuticalAnalysis,OfficeofTestingandResearch,CenterforDrugEvaluationandResearch,U.S.FoodandDrugAdministration,SilverSpring,MD,USA;bCenterforBiomedicalMassSpectrometryResearch,MedicalCollegeofWisconsin,Milwaukee,WI,USA;cBiomolecularMeasurementDivision,NationalInstit
6、uteofStandardsandTechnology,InstituteforBioscienceandBiotechnologyResearch,Rockville,MD,USA;dOfficeofLifecycleDrugProducts,OfficeofPharmaceuticalQuality,CenterforDrugEvaluationandResearch,U.S.FoodandDrugAdministration,SilverSpring,MD,USA;eCOURPharmaceuticalsDevelopmentCompany,Nor
7、thbrook,IL,USAABSTRACTARTICLEHISTORYIntroduction:Massspectrometry(MS)iswidelyusedinthecharacterizationofbiomoleculesincludingReceived4March2016peptideandproteintherapeutics.ThesebiotechnologyproductshaveseenrapidgrowthoverthepastAccepted20April2018fewdecadesandcontinuetodominatet
8、heglobalpharmaceuticalmarket.AdvancesinM
